Journal
HUMAN VACCINES & IMMUNOTHERAPEUTICS
Volume 12, Issue 4, Pages 907-915Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/21645515.2015.1119345
Keywords
vaccine; genetic polymorphism; SNP; individualized vaccination; GWAS; immune response; antibodies; Influenza; Measles; systems biology
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Funding
- SNSF Ambizione Score program [PZ00P3_154709]
- Forschungsfond University of Basel
- Bangerter-Rhyner Stiftung
- Stiftungsinfektionskrankheiten Basel
- SystemsX program
- iPhD fellowship of the SystemsX.ch initiative in systems biology program
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Many host- and vaccine-specific factors modulate an antibody response. Host genetic polymorphisms, in particular, modulate the immune response in multiple ways on different scales. This review article describes how information on host genetic polymorphisms and corresponding immune cascades may be used to generate personalized vaccine strategies to optimize the antibody response.
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