Journal
HUMAN VACCINES & IMMUNOTHERAPEUTICS
Volume 12, Issue 4, Pages 886-893Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/21645515.2015.1136759
Keywords
neonate; pertussis; plasma cell; tetanus; trans-placental antibody
Categories
Funding
- icddr,b
- World Health Organization (WHO) - Bill and Melinda Gates Foundation [2010168947]
- Australian Agency for International Development (AusAID)
- Government of the People's Republic of Bangladesh
- Canadian International Development Agency (CIDA)
- Swedish International Development Cooperation Agency (Sida)
- Department for International Development, UK (DFID)
Ask authors/readers for more resources
The goal of this study was to explore the effects of trans-placental tetanus toxoid (TT) and pertussis (PT) antibodies on an infant's response to vaccination in the context of antenatal immunization with tetanus but not with pertussis. 38 mothers received a single dose of TT vaccine during pregnancy. Infants received tetanus and pertussis vaccines at 6, 10 and 14wk of age. TT and PT anti-IgG secretion by infant lymphocytes was measured at 15wk. Plasma antibodies were measured at 6wk (pre-vaccination), 15wk and 1 y of age. Prior to vaccination, TT and PT antibody were detected in 94.6% and 15.2% of infants. At 15wk anti-TT-IgG and anti-PT-IgG in plasma was increased by 7-9 fold over pre-vaccination levels, while at 1 y plasma anti-TT-IgG was decreased by approximately 5-fold from the peak and had returned to near the pre-vaccination level. At 1 y plasma anti-PT-IgG was decreased by 2-fold 1 yfrom the 15wk level. However, 89.5% and 82.3% of infants at 1 y had protective levels of anti-TT and anti-PT IgG, respectively. Pre-vaccination plasma IgG levels were associated with lower vaccine-specific IgG secretion by infant lymphocytes at 15wk (p < 0.10). This apparent inhibition was seen for anti-TT-IgG at both 15wk (p < 0.05) and t 1 y (p < 0.10) of age. In summary, we report an apparent inhibitory effect of passively derived maternal antibody on an infants' own antibody response to the same vaccine. However, since the cut-off values for protective titers are low, infants had protective antibody levels throughout infancy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available