Journal
VETERINARY RESEARCH
Volume 54, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s13567-023-01156-y
Keywords
Non-aureus staphylococci; priming; Streptococcus uberis; Staphylococcus chromogenes; bovine mastitis; dairy cow
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Bovine mastitis, caused by Streptococcus uberis, has significant economic consequences. In this study, priming the murine mammary gland with Staphylococcus chromogenes IM was able to reduce the growth of S. uberis, potentially through the activation of the innate immune system by increasing IL-8 and LCN2.
Streptococcus uberis is a major causative agent of bovine mastitis, an inflammation of the mammary gland with substantial economic consequences. To reduce antibiotic use in animal agriculture, alternative strategies to treat or prevent mastitis are being investigated. Bovine-associated non-aureus staphylococci are proposed in that respect due to their capacity to inhibit the in vitro growth of S. uberis. We demonstrate that priming the murine mammary gland with Staphylococcus chromogenes IM reduces S. uberis growth in comparison with non-primed glands. The innate immune system is activated by increasing IL-8 and LCN2, which may explain this decreased growth.
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