Positive end-expiratory pressure induced changes in airway driving pressure in mechanically ventilated COVID-19 Acute Respiratory Distress Syndrome patients

Article Critical Care Medicine

Lung Response to a Higher Positive End-Expiratory Pressure in Mechanically Ventilated Patients With COVID-19

Alessandro Protti et al.

Summary: Patients with early ARDS due to COVID-19 have a large potential for lung recruitment, but their compliance and Pa-CO2 may not improve with higher PEEP, possibly due to hyperinflation.

CHEST (2022)

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Article Physiology

Hemodynamic response to positive end-expiratory pressure and prone position in COVID-19 ARDS

Antonio Maria Dell'Anna et al.

Summary: In patients with moderate-to-severe ARDS due to COVID-19, both high PEEP and prone position can improve arterial oxygenation. The effect of PEEP is influenced by changes in cardiac output, while prone position has a better effect on oxygenation without causing hemodynamic side effects.

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY (2022)

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Article Critical Care Medicine

Partition of respiratory mechanics in patients with acute respiratory distress syndrome and association with outcome: a multicentre clinical study

Lu Chen et al.

Summary: This study aimed to investigate the association between physiological parameters and 60-day outcome in patients with ARDS. The results showed that transpulmonary pressures and airway driving pressures were associated with 60-day mortality, while elastance-derived plateau P-L was not. A positive end-expiratory P-L was associated with better outcome in obese patients.

INTENSIVE CARE MEDICINE (2022)

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Article Critical Care Medicine

Clinical characteristics and outcomes of invasively ventilated patients with COVID-19 in Argentina (SATICOVID): a prospective, multicentre cohort study

Elisa Estenssoro et al.

Summary: The study investigated invasively ventilated COVID-19 patients in Argentina, where lung-protective ventilation was widely used but mortality remained high. Predictors of mortality in this study were largely consistent with findings from high-income countries.

LANCET RESPIRATORY MEDICINE (2021)

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Article Critical Care Medicine

An appraisal of respiratory system compliance in mechanically ventilated covid-19 patients

Gianluigi Li Bassi et al.

Summary: This study provides a comprehensive account of C-RS in COVID-19 patients on mechanical ventilation, showing its association with ventilatory management and outcomes. The C-RS measured within 48 hours from commencement of mechanical ventilation has marginal predictive value for 28-day mortality.

CRITICAL CARE (2021)

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