Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 24, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/ijms24054738
Keywords
type 2 diabetes; genetic susceptibility; molecular mechanisms; oxidative stress; redox homeostasis; glutathione metabolism; antioxidant enzymes; oxidative enzymes; single nucleotide polymorphism
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Numerous studies have shown that oxidative stress plays a major role in the development and progression of type 2 diabetes (T2D). This review summarizes the current understanding of the role of abnormal redox homeostasis in the molecular mechanisms of T2D and discusses the genetic studies investigating the contribution of polymorphisms in genes encoding redox state-regulating enzymes to the disease pathogenesis.
Numerous studies have shown that oxidative stress resulting from an imbalance between the production of free radicals and their neutralization by antioxidant enzymes is one of the major pathological disorders underlying the development and progression of type 2 diabetes (T2D). The present review summarizes the current state of the art advances in understanding the role of abnormal redox homeostasis in the molecular mechanisms of T2D and provides comprehensive information on the characteristics and biological functions of antioxidant and oxidative enzymes, as well as discusses genetic studies conducted so far in order to investigate the contribution of polymorphisms in genes encoding redox state-regulating enzymes to the disease pathogenesis.
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