A trinuclear cobalt coordination complex constructed using novel triazine ligands via one-pot green synthesis: structural properties and biological evaluation

New triazine ligands C3H5N5O (L1) and C5H5N5O3 (H(2)L2) were synthesised by reacting diaminoguanidine hydrochloride and glyoxylic acid in 1 : 1 and 1 : 2 molar ratios, respectively, at 150 degrees C in a green solvent (water). The corresponding cobalt complex, [Co-3(L1)(2)(L2)(4)]center dot 4H(2)O (1), was synthesised via a one-pot green synthesis process and was subsequently characterised by spectroscopic and elemental analysis methods. The structure of the cobalt complex was determined via single crystal X-ray diffraction analysis. Two types of ligands were observed in the cobalt complex: neutral (L1) and anionic (H(2)L2) ligands. The asymmetric unit was composed of one and a half crystallographically independent Co atoms, one L1 and two L2(2)(-) ligands, and two lattice water molecules. Interestingly, the core structure of the complex had a neutral mixed-valence Co(iii)-Co(ii)-Co(iii) trimer, and the overall neutrality of the complex was achieved because of the di-ionic nature of the H(2)L2 ligand. The spectral, thermal, and biological properties of the complex were explored, and biological aspects, such as antioxidant activity, protein binding and cytotoxicity, were examined. An assessment of the antioxidant activity of the compounds indicated better scavenging activity against ABTS(+), DPPH, O-2(-), and NO radicals than the known scavengers butylated hydroxyl anisole and ascorbic acid. The cobalt complex showed potential cytotoxicity toward MCF-7 cancer cells and was capable of inducing apoptosis.

Automated summary

New triazine ligands C3H5N5O (L1) and C5H5N5O3 (H(2)L2) were synthesized using diaminoguanidine hydrochloride and glyoxylic acid as precursors. The corresponding cobalt complex, [Co-3(L1)(2)(L2)(4)]center dot 4H(2)O (1), was synthesized through a one-pot green synthesis process and characterized using spectroscopic and elemental analysis methods. The cobalt complex exhibited promising antioxidant activity, protein binding, and cytotoxicity towards MCF-7 cancer cells, indicating its potential as a therapeutic agent.