Gate-voltage-modulated electrostatic interaction between the probe and the channel material of FET biosensors for detecting telomerase

A gate-voltage-modulated strategy was proposed to improve the detection performance of telomerase. We comprehensively investigated the mechanism for the gate-voltage-modulated detection performance by modulating the electrostatic interaction between charges of a single-stranded DNA probe and electrons of the In2O3 channel. This gate-voltage-modulated interaction between the probe and the channel can potentially serve as a universal strategy for high-performance FET biosensors.

Automated summary

A gate-voltage-modulated strategy was proposed to enhance the detection performance of telomerase. The mechanism for the improved detection performance was comprehensively investigated by modulating the electrostatic interaction between a single-stranded DNA probe and electrons of the In2O3 channel. This gate-voltage modulation could potentially be utilized as a universal strategy for high-performance FET biosensors.