DMSO/tBuONa/O2-mediated efficient syntheses of diverse quinoxalines through α-imino radicals

Herein, we describe an efficient method involving the synthesis of diverse quinoxalines using the DMSO/(BuONa)-Bu-t/O-2 system as a single-electron oxidant to form alpha-imino radicals and nitrogen radicals for the direct construction of C-N bonds. This methodology provides a novel approach to form alpha-imino radicals with good reactivity.

Automated summary

In this study, we developed an efficient method for synthesizing diverse quinoxalines using the DMSO/(BuONa)-Bu-t/O-2 system as a single-electron oxidant. The method involves the formation of alpha-imino radicals and nitrogen radicals, which directly construct C-N bonds. This approach offers a novel way to generate alpha-imino radicals with high reactivity.