Journal
ORGANIC CHEMISTRY FRONTIERS
Volume 10, Issue 10, Pages 2465-2470Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d3qo00310h
Keywords
-
Categories
Ask authors/readers for more resources
Copper-catalyzed regioselective and scalable 1,2-alkylarylation of vinylarenes was achieved under redox-neutral conditions. Diversely functionalized 1,1-diarylalkanes were easily synthesized with excellent functional group tolerance and high efficiency. Mechanistic studies suggested copper-catalyzed radical addition to olefin followed by Friedel-Crafts type alkylation, potentially involving benzylic cation intermediates.
Copper-catalyzed three-component regioselective and scalable 1,2-alkylarylation of vinylarenes was achieved under redox-neutral conditions. A variety of diversely functionalized 1,1-diarylalkanes were easily constructed by this strategy with excellent functional group tolerance and high efficiency. Mechanistic studies indicated that the reaction proceeded via a copper-catalyzed radical addition to an olefin followed by Friedel-Crafts type alkylation, with benzylic cation intermediates possibly involved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available