Journal
INORGANIC CHEMISTRY FRONTIERS
Volume 10, Issue 9, Pages 2665-2676Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d3qi00169e
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In this study, we report a method for preparing nanosized gadolinium (Gd-LTL) zeolite crystals for oxygen delivery and magnetic resonance imaging (MRI). The nanosized Gd-LTL zeolite showed high colloidal stability and remarkable crystallinity, with no leaching of gadolinium ions observed. In addition, the in vitro toxicity study revealed no toxicity for nanosized K-LTL and Gd-LTL zeolites even at high concentrations. This study provides promising guidelines for the design of smart biocompatible nanosized zeolites with gas-delivery and MRI properties.
The key challenges in finding efficient gas carriers for biomedical applications are related to the kinetics of gas adsorption/desorption of non-toxic materials over appropriate time intervals, specifically targeting the affected area. Herein, we report the preparation of nanosized gadolinium (Gd-LTL) zeolite crystals with a diameter of 10-15 nm for oxygen delivery combined with a magnetic resonance imaging (MRI) study. The partial ion-exchange of potassium (K) extra framework cations used for the synthesis of nanosized K-LTL zeolite with paramagnetic gadolinium (Gd, 1.53 wt%) changed its adsorption capacity for O-2 considerably. The nanosized Gd-LTL zeolite retained high colloidal stability and remarkable crystallinity, and no leaching of Gd ions was observed. In addition, the in vitro toxicity study performed in human glioblastoma-derived cell lines revealed that nanosized K-LTL and Gd-LTL nanosized zeolites showed no toxicity, even at high concentrations. This study provides promising guidelines regarding the design of smart biocompatible nanosized zeolites coupling gas-delivery and MRI properties.
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