Journal
FRONTIERS IN AGING NEUROSCIENCE
Volume 8, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnagi.2016.00303
Keywords
ubiquitin; deubiquitinating enzyme; proteasome; Alzheimer's disease; Parkinson's disease; Huntington's disease
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Funding
- National Natural Science Foundation of China [81571176, 91332114, U1405222]
- Thousand Young Talents Program of China
- Fundamental Research Funds for the Chinese Central Universities [20720150061]
- US National Institutes of Health [R01 AG038710, R01 AG021173, R01 NS046673, R01 AG030197, R01 AG044420]
- Alzheimer's Association
- Global Down Syndrome Foundation [DSADIIP-13-283543]
- BrightFocus Foundation
- Cure Alzheimer's Fund
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The ubiquitin-proteasome system (UPS) is one of the major protein degradation pathways, where abnormal UPS function has been observed in cancer and neurological diseases. Many neurodegenerative diseases share a common pathological feature, namely intracellular ubiquitin-positive inclusions formed by aggregate-prone neurotoxic proteins. This suggests that dysfunction of the UPS in neurodegenerative diseases contributes to the accumulation of neurotoxic proteins and to instigate neurodegeneration. Here, we review recent findings describing various aspects of UPS dysregulation in neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and Huntington's disease.
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