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Evolution of nanostructured skin patches towards multifunctional wearable platforms for biomedical applications

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Summary: This study presents a novel method for preparing 3D scaffolds with customizable biomolecule gradients based on photochemistry, which can achieve different gradients in fibers and influence the activity of cancer cells. This technology has the potential to provide a new tool for tissue engineering and disease modeling.

MATERIALS TODAY COMMUNICATIONS (2021)

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Review Chemistry, Multidisciplinary

Emerging Functional Biomaterials as Medical Patches

Yu Wang et al.

Summary: Medical patches have been widely explored and applied in various medical fields, achieving great success as multifunctional medical devices. They are used in wound healing, tissue engineering, drug delivery, and real-time health monitoring, attracting extensive attention and research interest. Challenges and prospects for the future development of medical patches are also discussed in research.

ACS NANO (2021)

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Article Engineering, Biomedical

Multifunctional ultrasmall AgNP hydrogel accelerates healing of S. aureus infected wounds

Hanif Haidari et al.

Summary: This study presents the development of a multifunctional thermo-responsive hydrogel utilizing ultra-small silver nanoparticles for controlled and optimized delivery of silver to infected wounds. The developed hydrogel showed significant elimination of S. aureus from mouse wounds, promoting cell proliferation and wound re-epithelization. The multifunctional properties of the AgNP thermoresponsive hydrogel offer great clinical potential in controlling bacterial infections and promoting wound healing.

ACTA BIOMATERIALIA (2021)

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Article Chemistry, Multidisciplinary

An Intelligent Transdermal Formulation of ALA-Loaded Copolymer Thermogel with Spontaneous Asymmetry by Using Temperature-Induced Sol-Gel Transition and Gel-Sol (Suspension) Transition on Different Sides

Dinglingge Cao et al.

Summary: This study introduces a novel composite hydrogel formulation utilizing both sol-gel and gel-sol (suspension) transitions for efficient photodynamic therapy of skin diseases. By adjusting the blending ratio, the transition temperatures of the formulation can be easily controlled, allowing for rapid release and improved efficacy. The concept is supported by various experiments including characterization of biomaterials, drug release profiles, cell experiments, in vitro permeation, and in vivo transdermal delivery studies.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Chemistry, Analytical

Intelligent Patches for Wound Management: In Situ Sensing and Treatment

Yuqiu Wang et al.

Summary: Intelligent wound patches have potential properties such as ultra-adhesion, self-healing ability, biosensing, antibacterial, and anti-inflammatory effects. There is a need for further exploration in in situ sensing and intelligent drug delivery, and new strategies are crucial in this regard. Challenges exist in this field, but there are promising opportunities for future developments.

ANALYTICAL CHEMISTRY (2021)

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Article Chemistry, Physical

Human body-based self-powered wearable electronics for promoting wound healing driven by biomechanical motions

Dong Wan et al.

Summary: A flexible and stretchable self-powered wearable patch was developed in this study, utilizing biomechanical motions to promote wound healing, marking a significant step in practical applications of wearable medical electronics.

NANO ENERGY (2021)

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Review Engineering, Environmental

Biomaterials- and biostructures Inspired high-performance flexible stretchable strain sensors: A review

Wei Wang et al.

Summary: Flexible stretchable strain sensors have gained significant attention for their excellent performance and comfort, with natural biomaterials and biostructures playing a crucial role in their development. Key nature-inspired structural designs such as cracks, brick-and-mortar, and wrinkled structures are highlighted in this review.

CHEMICAL ENGINEERING JOURNAL (2021)

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Review Multidisciplinary Sciences

Skin-like hydrogel devices for wearable sensing, soft robotics and beyond

Binbin Ying et al.

Summary: Skin-like electronics using hydrogels as soft biomaterials are being developed rapidly, facing challenges such as limited functionality, low ambient stability, poor surface adhesion, and relatively high power consumption. Current research is focused on increasing toughness, conductivity, and developing advanced features like anti-dehydration, anti-freezing, and improved adhesion for hydrogel devices in applications such as wearable electronics, soft robotics, and energy harvesting.

ISCIENCE (2021)

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Article Multidisciplinary Sciences

A wireless optoelectronic skin patch for light delivery and thermal monitoring

Han-Joon Kim et al.

Summary: The integration of a transparent nanowire sensor into a wearable optoelectronic patch allows for simultaneous light delivery and thermal monitoring, showing potential for advancements in light-based diagnostics and therapies.

ISCIENCE (2021)

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Article Multidisciplinary Sciences

A wearable patch for continuous analysis of thermoregulatory sweat at rest

Hnin Yin Yin Nyein et al.

Summary: The study presents wearable microfluidics-based patches for continuous sweat monitoring at rest, enabling detection of pH, Cl-, and levodopa for dynamic sweat analysis related to routine activities, stress events, hypoglycemia-induced sweating, and Parkinson's disease, thus allowing for continuous and autonomous monitoring of body physiology at rest.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

Self-powered ultraflexible photonic skin for continuous bio-signal detection via air-operation-stable polymer light-emitting diodes

Hiroaki Jinno et al.

Summary: The integration of ultraflexible optical sensors with power sources faces challenges due to the insufficient air operational stability of polymer light-emitting diodes. However, by combining air-operation-stable polymer light-emitting diodes, organic solar cells, and organic photodetectors, a self-powered organic optical system for photoplethysmogram monitoring has been developed. This system demonstrates high linearity and stability, making it suitable for long-term health monitoring applications.

NATURE COMMUNICATIONS (2021)

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Review Engineering, Biomedical

Accelerated Skin Wound Healing by Electrical Stimulation

Ruizeng Luo et al.

Summary: When the integrity of the skin is compromised, an endogenous electric field is generated to facilitate wound healing, while exogenous electric fields can assist in treating wounds that cannot heal on their own. The effects of exogenous electrical stimulation on wound healing involve inflammation, blood flow, cell proliferation and migration, and wound scarring. New electrical stimulation methods and devices are characterized by being safe, low-cost, stable, and small in size.

ADVANCED HEALTHCARE MATERIALS (2021)

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Article Biotechnology & Applied Microbiology

Sustained delivery of MMP-9 siRNA via thermosensitive hydrogel accelerates diabetic wound healing

Biyun Lan et al.

Summary: The hybrid hydrogel dressing developed for localized delivery of MMP-9 siRNA showed significant reduction in MMP-9 expression and improved diabetic wound closure in diabetic rats. The dressing exhibited negligible cytotoxicity in vitro and sustained release of siMMP-9 for up to 7 days. This delivery system offers a platform for in vivo delivery of siRNA for the treatment of various diseases.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Engineering, Biomedical

A suspended layer additive manufacturing approach to the bioprinting of tri-layered skin equivalents

Richard J. A. Moakes et al.

Summary: This study utilized suspended layer additive manufacturing to create a continuous tri-layered implant that closely resembles human skin. By carefully controlling the bioink composition, gradients of chemical and cellular components were formed, facilitating cellular remodeling of the supporting matrix and successful integration of the implant into surrounding tissues. This innovative approach shows promise in promoting healing and tissue regeneration within deep wounds.

APL BIOENGINEERING (2021)

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Article Chemistry, Physical

A Triboelectric-Electromagnetic Hybrid Nanogenerator with Broadband Working Range for Wind Energy Harvesting and a Self-Powered Wind Speed Sensor

Cuiying Ye et al.

Summary: The triboelectric-electromagnetic hybrid nanogenerator (FTEHG) effectively harvests various levels of wind energy, broadening the working range of wind speed and showing potential for self-powered weather monitoring applications.

ACS ENERGY LETTERS (2021)

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Article Chemistry, Multidisciplinary

Touch-Based Fingertip Blood-Free Reliable Glucose Monitoring: Personalized Data Processing for Predicting Blood Glucose Concentrations

Juliane R. Sempionatto et al.

Summary: The study presents a new rapid and reliable approach that combines a simple touch-based fingertip sweat electrochemical sensor with a new algorithm for accurate estimation of blood glucose concentrations. The painless and simple glucose self-testing protocol leverages the fast sweat rate on the fingertip for rapid assays of natural perspiration, without any sweat stimulation, in addition to personalized sweat-response-to-blood concentration translation.

ACS SENSORS (2021)

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Article Multidisciplinary Sciences

Tissue-like skin-device interface for wearable bioelectronics by using ultrasoft, mass-permeable, and low-impedance hydrogels

Chanhyuk Lim et al.

Summary: Hydrogels, composed of a cross-linked polymer network and water molecules, show similar mechanical structures and properties to human tissue, making them ideal for creating tissue-like interfaces between wearable devices and skin. Functionalized hydrogels with high mass-permeability and low impedance play a crucial role in enhancing the performance of wearable bioelectronics by forming a conformal interface on the skin.

SCIENCE ADVANCES (2021)

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Article Pharmacology & Pharmacy

Hybrid 3D Printing of Advanced Hydrogel-Based Wound Dressings with Tailorable Properties

Marko Milojevic et al.

Summary: The hybrid extrusion-based bioprinting process allows for the fabrication of mechanically advantageous scaffolds by integrating softer hydrogels into a stiffer synthetic framework. This approach enables the fine-tuning of wettability, swelling, degradability, and mechanical strength, while providing a gradient of surface properties and good biocompatibility for tissue engineering applications. The controlled degradability and permeability of the hydrogel component may also enable controlled drug delivery in these hybrid scaffolds.

PHARMACEUTICS (2021)

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Article Materials Science, Composites

Bioinspired sequentially crosslinked nanofibrous hydrogels with robust adhesive and stretchable capability for joint wound dressing

Yuqi Zheng et al.

Summary: Inspired by the protein secretion-curing process of natural marine mussels, an adhesive nanofibrous hydrogel was developed using a sequential crosslinking strategy. The hydrogel showed superior adhesive and tensile properties, accelerating wound healing and demonstrating great potential for joint wound care.

COMPOSITES COMMUNICATIONS (2021)

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Article Engineering, Biomedical

A design approach for layer-by-layer surface-mediated siRNA delivery

Jonathan J. Chou et al.

Summary: This study investigates the effects of LbL assembly parameters on film composition and siRNA-mediated gene knockdown efficiency, highlighting the importance of optimizing assembly conditions for surface-mediated delivery systems. The work provides a significant step towards promoting transfection efficacy while reducing material and processing requirements in LbL delivery systems.

ACTA BIOMATERIALIA (2021)

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Review Pharmacology & Pharmacy

Biomaterial-based delivery of nucleic acids for tissue regeneration

Yaping Zhuang et al.

Summary: Gene therapy for tissue regeneration is promising but faces limitations in vivo due to physiological obstacles. Biomaterial-based gene delivery systems can overcome stability issues and control overexpression of therapeutic genes, contributing to local production of regulatory factors.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Article Chemistry, Multidisciplinary

Stretchable and Highly Permeable Nanofibrous Sensors for Detecting Complex Human Body Motion

Yehu David Horev et al.

Summary: A highly gas-permeable ultra-thin strain sensor has been developed by covalently grafting nanofibrous polyaniline (PANI) onto stretchable elastomer nanomeshes, demonstrating low weight, intimate connection with skin, stable performance, and continuous recording of complex movements.

ADVANCED MATERIALS (2021)

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Review Chemistry, Multidisciplinary

Energy Autonomous Sweat-Based Wearable Systems

Libu Manjakkal et al.

Summary: Research has shown that sweat-based energy generation and storage technologies can provide sustainable and safe power for wearable electronic devices. These technologies have high power and energy densities to meet the energy needs in various applications.

ADVANCED MATERIALS (2021)

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Review Engineering, Biomedical

Wound Healing: From Passive to Smart Dressings

Mojtaba Farahani et al.

Summary: The universal increase in the number of patients with nonhealing skin wounds imposes a huge social and economic burden. The recent advances in materials and fabrication technologies have led to the development of smart wound dressings, such as 3D-printed dressings and biomolecule-loaded dressings, which accelerate wound healing and provide effective wound care management strategies.

ADVANCED HEALTHCARE MATERIALS (2021)

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Review Chemistry, Physical

Nanotechnology-Assisted RNA Delivery: From Nucleic Acid Therapeutics to COVID-19 Vaccines

Chiara Rinoldi et al.

Summary: This article reviews the latest developments in RNA therapy, focusing on the development, characteristics, and applications of nanotechnology-assisted RNA delivery drugs. It discusses the importance and challenges of RNA drugs in the field of treatment, as well as possible future directions for development.

SMALL METHODS (2021)

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Article Materials Science, Multidisciplinary

Plasma assisted design of biocompatible 3D printed PCL/silver nanoparticle scaffolds: in vitro and in vivo analyses

Neethu Ninan et al.

Summary: 3D printing offers opportunities for designing tissue engineering constructs with specific properties, this study successfully fabricated silver nanoparticle functionalized PCL scaffolds with good mechanical performance and biocompatibility.

MATERIALS ADVANCES (2021)

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Article Chemistry, Multidisciplinary

Macrophage reprogramming into a pro-healing phenotype by siRNA delivered with LBL assembled nanocomplexes for wound healing applications

Maryam Sharifiaghdam et al.

Summary: This study presents a novel selenium-based layer-by-layer nanocomplex for delivering irf5-siRNA to modulate macrophage polarization and enhance wound healing.

NANOSCALE (2021)

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Article Materials Science, Biomaterials

Injectable, self-healing and pH responsive stem cell factor loaded collagen hydrogel as a dynamic bioadhesive dressing for diabetic wound repair

Li Zhang et al.

Summary: The Col/APG hydrogel loaded with stem cell factor is effective in treating diabetic ulcers, enhancing adhesive strength and promoting cellular response, collagen deposition, and neovascularization in a diabetic rat model. The presence of M2 macrophages in the hydrogel groups suggests potential anti-inflammatory effects and tissue regeneration benefits.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Article Materials Science, Multidisciplinary

An injectable serotonin-chondroitin sulfate hydrogel for bio-inspired hemostatic adhesives with high wound healing capability

Xingxia Zhang et al.

Summary: A new hydrogel inspired by platelet coagulation mediator has been developed with improved hemostatic performance and wound healing capability. The hydrogel is prepared using highly biocompatible serotonin and chondroitin sulfate, exhibiting rapid hemostasis and wound healing.

MATERIALS ADVANCES (2021)

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Review Nanoscience & Nanotechnology

Wearable and Biodegradable Sensors for Human Health Monitoring

Yang Li et al.

Summary: The wearable sensor industry is growing rapidly, with significant progress made despite challenges due to immature technologies. Latest research focuses on material selection, structure design, and application exploration, especially emphasizing implantable sensors made from biodegradable materials.

ACS APPLIED BIO MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Injectable, self-healing mesoporous silica nanocomposite hydrogels with improved mechanical properties

A. Zengin et al.

Summary: By chemically crosslinking thiol-functionalized mesoporous silica nanoparticles with hydrophilic polymers such as polyethylene glycol, nanocomposites with high storage modulus and rapid self-healing capabilities were successfully formed. This approach offers a promising strategy to create multifunctional self-healing biomaterials for a wider range of applications in regenerative medicine.

NANOSCALE (2021)

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Review Biotechnology & Applied Microbiology

Soft and flexible material-based affinity sensors

Lingyin Meng et al.

BIOTECHNOLOGY ADVANCES (2020)

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Review Chemistry, Multidisciplinary

Advanced Soft Materials, Sensor Integrations, and Applications of Wearable Flexible Hybrid Electronics in Healthcare, Energy, and Environment

Hyo-Ryoung Lim et al.

ADVANCED MATERIALS (2020)

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Review Chemistry, Multidisciplinary

Mimicking Human and Biological Skins for Multifunctional Skin Electronics

Youngoh Lee et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Engineering, Biomedical

Exosome loaded alginate hydrogel promotes tissue regeneration in full-thickness skin wounds: An in vivo study

Shilan Shafei et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2020)

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Article Materials Science, Multidisciplinary

Ion selective textile organic electrochemical transistor for wearable sweat monitoring

Nicola Coppede et al.

ORGANIC ELECTRONICS (2020)

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Review Nanoscience & Nanotechnology

Inorganic Biomaterials for Regenerative Medicine

Anna M. Brokesh et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Nanoscience & Nanotechnology

Fast and High Strength Soft Tissue Bioadhesives Based on a Peptide Dendrimer with Antimicrobial Properties and Hemostatic Ability

Haofang Zhu et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Nanoscience & Nanotechnology

Wireless Single-Electrode Self-Powered Piezoelectric Sensor for Monitoring

Qi Liu et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Nanoscience & Nanotechnology

Dual pH-Responsive Hydrogel Actuator for Lipophilic Drug Delivery

Zilong Han et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Chemistry, Multidisciplinary

Muscle-Inspired Self-Healing Hydrogels for Strain and Temperature Sensor

Gang Ge et al.

ACS NANO (2020)

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Article Chemistry, Multidisciplinary

Continuous Energy Harvesting and Motion Sensing from Flexible Electrochemical Nanogenerators: Toward Smart and Multifunctional Textiles

Murtaza Zohair et al.

ACS NANO (2020)

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Article Chemistry, Multidisciplinary

All-Fiber Structured Electronic Skin with High Elasticity and Breathability

Zhaoling Li et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Mechanically Interlocked Hydrogel-Elastomer Hybrids for On-Skin Electronics

Shaowu Pan et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Electrochemical Sensors, a Bright Future in the Fabrication of Portable Kits in Analytical Systems

Hassan Karimi-Maleh et al.

CHEMICAL RECORD (2020)

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Article Pharmacology & Pharmacy

SEBS block copolymers as novel materials to design transdermal patches

Chiara Grazia Milena Gennari et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

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Article Pharmacology & Pharmacy

Collagen scaffold-mediated delivery of NLC/siRNA as wound healing materials

Ozgul Tezgel et al.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2020)

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Article Chemistry, Multidisciplinary

Autonomic Self-Healing of PEDOT:PSS Achieved Via Polyethylene Glycol Addition

Yang Li et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Chemistry, Multidisciplinary

A Patch of Detachable Hybrid Microneedle Depot for Localized Delivery of Mesenchymal Stem Cells in Regeneration Therapy

KangJu Lee et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Engineering, Biomedical

Upconversion Nanoparticle Powered Microneedle Patches for Transdermal Delivery of siRNA

Min Wang et al.

ADVANCED HEALTHCARE MATERIALS (2020)

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Article Polymer Science

Controllable Drug Release Behavior of Polylactic Acid (PLA) Surgical Suture Coating with Ciprofloxacin (CPFX)-Polycaprolactone (PCL)/Polyglycolide (PGA)

Shuqiang Liu et al.

POLYMERS (2020)

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Article Chemistry, Physical

Highly shape adaptive fiber based electronic skin for sensitive joint motion monitoring and tactile sensing

Miaomiao Zhu et al.

NANO ENERGY (2020)

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Article Polymer Science

High strength, antifreeze, and moisturizing conductive hydrogel for human-motion detection

Yinjie Peng et al.

POLYMER (2020)

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Article Polymer Science

Influence of Ultraviolet Radiation Exposure Time on Styrene-Ethylene-Butadiene-Styrene (SEBS) Copolymer

Daniel Garcia-Garcia et al.

POLYMERS (2020)

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Article Chemistry, Multidisciplinary

Ultraviolet Light-Assisted Electrospinning of Core-Shell Fully Cross-Linked P(NIPAAm-co-NIPMAAm) Hydrogel-Based Nanofibers for Thermally Induced Drug Delivery Self-Regulation

Sylwia Pawlowska et al.

ADVANCED MATERIALS INTERFACES (2020)

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Review Materials Science, Biomaterials

Skin-Patchable Electrodes for Biosensor Applications: A Review

Nagaraj P. Shetti et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2020)

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Review Chemistry, Multidisciplinary

Metal Oxides-Based Semiconductors for Biosensors Applications

Ionel Serban et al.

FRONTIERS IN CHEMISTRY (2020)

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Article Nanoscience & Nanotechnology

Multilayer Alginate-Polycaprolactone Electrospun Membranes as Skin Wound Patches with Drug Delivery Abilities

Andrea Dodero et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Engineering, Biomedical

Injectable redox and light responsive MnO2 hybrid hydrogel for simultaneous melanoma therapy and multidrug-resistant bacteria-infected wound healing

Shenqiang Wang et al.

BIOMATERIALS (2020)

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Article Polymer Science

Rapidly curable hyaluronic acid-catechol hydrogels inspired by scallops as tissue adhesives for hemostasis and wound healing

Dandan Wang et al.

EUROPEAN POLYMER JOURNAL (2020)

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Article Chemistry, Physical

On-skin graphene electrodes for large area electrophysiological monitoring and human-machine interfaces

Zhuo Li et al.

CARBON (2020)

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Article Chemistry, Physical

Energy autonomous hybrid electronic skin with multi-modal sensing capabilities

Miaomiao Zhu et al.

NANO ENERGY (2020)

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Article Materials Science, Biomaterials

Novel ECM Patch Combines Poly(vinyl alcohol), Human Fibroblast-Derived Matrix, and Mesenchymal Stem Cells for Advanced Wound Healing

Sang Su Ha et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2020)

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Article Nanoscience & Nanotechnology

PEDOT:PSS Microchannel-Based Highly Sensitive Stretchable Strain Sensor

Mitradip Bhattacharjee et al.

ADVANCED ELECTRONIC MATERIALS (2020)

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Article Nanoscience & Nanotechnology

Multifunctional Poly(vinyl alcohol) Nanocomposite Organohydrogel for Flexible Strain and Temperature Sensor

Jianfeng Gu et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Chemistry, Multidisciplinary

Adhesive Hydrogel Patch with Enhanced Strength and Adhesiveness to Skin for Transdermal Drug Delivery

Hooyeon Jung et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Converting 2D Nanofiber Membranes to 3D Hierarchical Assemblies with Structural and Compositional Gradients Regulates Cell Behavior

Shixuan Chen et al.

ADVANCED MATERIALS (2020)

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Article Biochemistry & Molecular Biology

Tailoring the Self-Healing Properties of Conducting Polymer Films

Yang Li et al.

MACROMOLECULAR BIOSCIENCE (2020)

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Article Biochemistry & Molecular Biology

Dual Oral Tissue Adhesive Nanofiber Membranes for pH-Responsive Delivery of Antimicrobial Peptides

Sunil Kumar Boda et al.

BIOMACROMOLECULES (2020)

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Article Chemistry, Physical

Bioinspired hybrid patches with self-adhesive hydrogel and piezoelectric nanogenerator for promoting skin wound healing

Shuo Du et al.

NANO RESEARCH (2020)

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Article Multidisciplinary Sciences

Intrinsically stretchable electrode array enabled in vivo electrophysiological mapping of atrial fibrillation at cellular resolution

Jia Liu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Engineering, Biomedical

Highly Sensitive Flexible Iontronic Pressure Sensor for Fingertip Pulse Monitoring

Qiupeng Lin et al.

ADVANCED HEALTHCARE MATERIALS (2020)

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Article Polymer Science

Development of Biodegradable Cosmetic Patch Using a Polylactic Acid/Phycocyanin-Alginate Composite

Sarah Amalina Adli et al.

POLYMERS (2020)

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Article Multidisciplinary Sciences

Wireless battery-free wearable sweat sensor powered by human motion

Yu Song et al.

SCIENCE ADVANCES (2020)

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Article Nanoscience & Nanotechnology

Multifunctional Platform Based on Electrospun Nanofibers and Plasmonic Hydrogel: A Smart Nanostructured Pillow for Near-Infrared Light-Driven Biomedical Applications

Pawel Nakielski et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Multidisciplinary Sciences

Skin-interfaced microfluidic system with personalized sweating rate and sweat chloride analytics for sports science applications

Lindsay B. Baker et al.

SCIENCE ADVANCES (2020)

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Article Nanoscience & Nanotechnology

Poly(vinyl alcohol) and Functionalized Ionic Liquid-Based Smart Hydrogels for Doxorubicin Release

Muzammil Kuddushi et al.

ACS APPLIED BIO MATERIALS (2020)

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Article Engineering, Multidisciplinary

Study on mussel-inspired tough TA/PANI@CNCs nanocomposite hydrogels with superior self-healing and self-adhesive properties for strain sensors

Qiming Yan et al.

COMPOSITES PART B-ENGINEERING (2020)

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Article Materials Science, Biomaterials

Directed vertical cell migration via bifunctionalized nanomaterials in 3D step-gradient nanocomposite hydrogels

Andisheh Motealleh et al.

BIOMATERIALS SCIENCE (2020)

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Article Nanoscience & Nanotechnology

Self-Powered Wearable Piezoelectric Sensors Based on Polymer Nanofiber-Metal-Organic Framework Nanoparticle Composites for Arterial Pulse Monitoring

Bentolhoda Hadavi Moghadam et al.

ACS APPLIED NANO MATERIALS (2020)

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Article Materials Science, Biomaterials

A natural polymer based bioadhesive with self-healing behavior and improved antibacterial properties

Xiang Ke et al.

BIOMATERIALS SCIENCE (2020)

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Article Chemistry, Multidisciplinary

Temperature/near-infrared light-responsive conductive hydrogels for controlled drug release and real-time monitoring

Yuting Zhu et al.

NANOSCALE (2020)

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Article Materials Science, Biomaterials

A near-infrared light-responsive multifunctional nanocomposite hydrogel for efficient and synergistic antibacterial wound therapy and healing promotion

Na Yang et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Article Materials Science, Multidisciplinary

Hydrogen-Bonding Reinforced Injectable Hydrogels: Application As a Thermo-Triggered Drug Controlled-Release System

Dong Wang et al.

ACS APPLIED POLYMER MATERIALS (2020)

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Review Engineering, Electrical & Electronic

Flexible inorganic bioelectronics

Ying Chen et al.

NPJ FLEXIBLE ELECTRONICS (2020)

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Review Materials Science, Multidisciplinary

Designing multigradient biomaterials for skin regeneration

M. Rahmati et al.

MATERIALS TODAY ADVANCES (2020)

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Article Chemistry, Physical

pH-responsive injectable hydrogels with mucosal adhesiveness based on chitosan-grafted-dihydrocaffeic acid and oxidized pullulan for localized drug delivery

Yongping Liang et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2019)

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Article Polymer Science

Electro-responsive polyacrylamide-grafted-gum ghatti copolymer for transdermal drug delivery application

Ravindra P. Birajdar et al.

JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY (2019)

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Article Materials Science, Biomaterials

Fabrication of gradient porous microneedle array by modified hot embossing for transdermal drug delivery

Jiyu Li et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

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Article Chemistry, Multidisciplinary

Adhesive Hemostatic Conducting Injectable Composite Hydrogels with Sustained Drug Release and Photothermal Antibacterial Activity to Promote Full-Thickness Skin Regeneration During Wound Healing

Yongping Liang et al.

SMALL (2019)

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Article Multidisciplinary Sciences

Waterproof, electronics-enabled, epidermal microfluidic devices for sweat collection, biomarker analysis, and thermography in aquatic settings

Jonathan T. Reeder et al.

SCIENCE ADVANCES (2019)

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Article Materials Science, Multidisciplinary

Mussel-Inspired Hydrogel Composite with Multi-Stimuli Responsive Behavior

Yun-Hui Yan et al.

MACROMOLECULAR MATERIALS AND ENGINEERING (2019)

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Article Multidisciplinary Sciences

Symbiotic cardiac pacemaker

Han Ouyang et al.

NATURE COMMUNICATIONS (2019)

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Review Engineering, Biomedical

Multifunctional Biomedical Adhesives

Rattapol Pinnaratip et al.

ADVANCED HEALTHCARE MATERIALS (2019)

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Article Nanoscience & Nanotechnology

Tuning the Electromechanical Properties of PEDOT:PSS Films for Stretchable Transistors And Pressure Sensors

Shiming Zhang et al.

ADVANCED ELECTRONIC MATERIALS (2019)

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Article Chemistry, Multidisciplinary

A Flexible Piezoelectret Actuator/Sensor Patch for Mechanical Human-Machine Interfaces

Junwen Zhong et al.

ACS NANO (2019)

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Article Engineering, Biomedical

An injectable and tumor-specific responsive hydrogel with tissue-adhesive and nanomedicine-releasing abilities for precise locoregional chemotherapy

Di Wu et al.

ACTA BIOMATERIALIA (2019)

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Article Chemistry, Multidisciplinary

Highly Stretchable Metallic Nanowire Networks Reinforced by the Underlying Randomly Distributed Elastic Polymer Nanofibers via Interfacial Adhesion Improvement

Zhi Jiang et al.

ADVANCED MATERIALS (2019)

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Review Pharmacology & Pharmacy

An overview of electrospun membranes loaded with bioactive molecules for improving the wound healing process

Sonia P. Miguel et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2019)

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Editorial Material Multidisciplinary Sciences

Skin sensors are the future of health care

Shuai Xu et al.

NATURE (2019)

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Article Chemistry, Multidisciplinary

Local Immunomodulation Using an Adhesive Hydrogel Loaded with miRNA-Laden Nanoparticles Promotes Wound Healing

Bahram Saleh et al.

SMALL (2019)

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Article Multidisciplinary Sciences

Bioinspired mechanically active adhesive dressings to accelerate wound closure

S. O. Blacklow et al.

SCIENCE ADVANCES (2019)

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Biocompatible, self-wrinkled, antifreezing and stretchable hydrogel-based wearable sensor with PEDOT:sulfonated lignin as conductive materials

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CHEMICAL ENGINEERING JOURNAL (2019)

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Regional and correlative sweat analysis using high-throughput microfluidic sensing patches toward decoding sweat

Hnin Yin Yin Nyein et al.

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Bio-inspired swellable hydrogel-forming double-layered adhesive microneedle protein patch for regenerative internal/external surgical closure

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Biosynthesis and characterization of antibacterial thermosensitive hydrogels based on corn silk extract, hyaluronic acid and nanosilver for potential wound healing

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CARBOHYDRATE POLYMERS (2019)

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Self-Sustainable Wearable Textile Nano-Energy Nano-System (NENS) for Next-Generation Healthcare Applications

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Application of polycaprolactone, chitosan, and collagen composite as a nanofibrous mat loaded with silver sulfadiazine and growth factors for wound dressing

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Integrated textile sensor patch for real-time and multiplex sweat analysis

Wenya He et al.

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Bioinspired multifunctional biomaterials with hierarchical microstructure for wound dressing

Jianmin Xue et al.

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Culturing melanocytes and fibroblasts within three-dimensional macroporous PDMS scaffolds: towards skin dressing material

Neelima Varshney et al.

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Bioengineered smart trilayer skin tissue substitute for efficient deep wound healing

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A Fibrous Hybrid Patch Couples Cell-Derived Matrix and Poly(L-lactide-co-caprolactone) for Endothelial Cells Delivery and Skin Wound Repair

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Self-powered smart patch for sweat conductivity monitoring

Laura Ortega et al.

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Bioinspired Adhesive Architectures: From Skin Patch to Integrated Bioelectronics

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Incorporation of ZnO/Bioactive Glass Nanoparticles into Alginate/Chitosan Composite Hydrogels for Wound Closure

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ACS APPLIED BIO MATERIALS (2019)

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Recent advances in inorganic nanomaterials for wound-healing applications

Susheel Kumar Nethi et al.

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Multiple Cross-Linking-Dominated Metal-Ligand Coordinated Hydrogels with Tunable Strength and Thermosensitivity

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Copper-nanoparticle-embedded hydrogel for killing bacteria and promoting wound healing with photothermal therapy

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Mass-produced SEBS/graphite nanoplatelet composites with a segregated structure for highly stretchable and recyclable strain sensors

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Highly stretchable polystyrene sulfonate organic electrochemical transistors achieved via polyethylene glycol addition

Yang Li et al.

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Nanocrystalline cellulose-hyaluronic acid composite enriched with GM-CSF loaded chitosan nanoparticles for enhanced wound healing

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Stimuli-Responsive Multilayers Based on Thiolated Polysaccharides That Affect Fibroblast Cell Adhesion

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Self-Adapting Hydrogel to Improve the Therapeutic Effect in Wound-Healing

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Skin-Inspired Hierarchical Polymer Architectures with Gradient Stiffness for Spacer-Free, Ultrathin, and Highly Sensitive Triboelectric Sensors

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ACS NANO (2018)

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Delivery systems of current biologicals for the treatment of chronic cutaneous wounds and severe burns

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Drug delivery systems and materials for wound healing applications

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Energy Harvesting Research: The Road from Single Source to Multisource

Yang Bai et al.

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Dynamic Bonds between Boronic Acid and Alginate: Hydrogels with Stretchable, Self-Healing, Stimuli-Responsive, Remoldable, and Adhesive Properties

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Hydrogen bonds autonomously powered gelatin methacrylate hydrogels with super-elasticity, self-heal and underwater self-adhesion for sutureless skin and stomach surgery and E-skin

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Ceria nanocrystals decorated mesoporous silica nanoparticle based ROS-scavenging tissue adhesive for highly efficient regenerative wound healing

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Stretchable wireless system for sweat pH monitoring

Wenting Dang et al.

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Polydimethylsiloxane incorporated with reduced graphene oxide (rGO) sheets for wound dressing application: Preparation and characterization

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Electrospun polymeric nanofibres as wound dressings: A review

Sonia P. Miguel et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2018)

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Hydrogel wound dressings for bioactive treatment of acute and chronic wounds

Julia Koehler et al.

EUROPEAN POLYMER JOURNAL (2018)

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Electro-responsive graphene oxide hydrogels for skin bandages: The outcome of gelatin and trypsin immobilization

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Design and fabrication of a triple-responsive chitosan-based hydrogel with excellent mechanical properties for controlled drug delivery

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A fluorometric skin-interfaced microfluidic device and smartphone imaging module for in situ quantitative analysis of sweat chemistry

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LAB ON A CHIP (2018)

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Graphene Oxide Hybrid Supramolecular Hydrogels with Self-Healable, Bioadhesive and Stimuli-Responsive Properties and Drug Delivery Application

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Highly Conformable, Transparent Electrodes for Epidermal Electronics

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NANO LETTERS (2018)

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Theory, technology and applications of piezoresistive sensors: A review

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Multifunctional Smart Skin Adhesive Patches for Advanced Health Care

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In vitro fibroblast migration by sustained release of PDGF-BB loaded in chitosan nanoparticles incorporated in electrospun nanofibers for wound dressing applications

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Highly Adaptable and Biocompatible Octopus-Like Adhesive Patches with Meniscus-Controlled Unfoldable 3D Microtips for Underwater Surface and Hairy Skin

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Self-Powered Wearable Electrocardiography Using a Wearable Thermoelectric Power Generator

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ACS ENERGY LETTERS (2018)

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Rehealable, fully recyclable, and malleable electronic skin enabled by dynamic covalent thermoset nanocomposite

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Polymer-Based Nanomaterials for Photothermal Therapy: From Light-Responsive to Multifunctional Nanoplatforms for Synergistically Combined Technologies

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Antibacterial adhesive injectable hydrogels with rapid self-healing, extensibility and compressibility as wound dressing for joints skin wound healing

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A Multifunctional Metallohydrogel with Injectability, Self-Healing, and Multistimulus-Responsiveness for Bioadhesives

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An integrated self-healable electronic skin system fabricated via dynamic reconstruction of a nanostructured conducting network

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Thermoresponsive gels containing gold nanoparticles as smart antibacterial and wound healing agents

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Formulation, characterization and evaluation of mRNA-loaded dissolvable polymeric microneedles (RNApatch)

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A skin patch for sensing blood pressures

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NATURE BIOMEDICAL ENGINEERING (2018)

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Effective Wound Healing Enabled by Discrete Alternative Electric Fields from Wearable Nanogenerators

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Effective weight control via an implanted self-powered vagus nerve stimulation device

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Flexible Delivery Patch Systems based on Thermoresponsive Hydrogels and Submicronic Fiber Heaters

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Wearable sweat sensors

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Electrically stimulated cell migration and its contribution to wound healing

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BURNS & TRAUMA (2018)

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An overview of recent applications of reduced graphene oxide as a basis of electroanalytical sensing platforms

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APPLIED MATERIALS TODAY (2018)

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Self-Powered Noncontact Electronic Skin for Motion Sensing

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Silicon-dioxide-polyvinylpyrrolidone as a wound dressing for skin defects in a murine model

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Self-healing supramolecular hydrogel of poly(vinyl alcohol)/chitosan carbon dots

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Multifunctional, biocompatible and pH-responsive carbon nanotube- and graphene oxide/tectomer hybrid composites and coatings

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NANOSCALE (2017)

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Self-healing pH-sensitive cytosine- and guanosine-modified hyaluronic acid hydrogels via hydrogen bonding

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A pH, glucose, and dopamine triple-responsive, self-healable adhesive hydrogel formed by phenylborate-catechol complexation

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Synthesis of an injectable, self-healable and dual responsive hydrogel for drug delivery and 3D cell cultivation

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POLYMER CHEMISTRY (2017)

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Autonomous sweat extraction and analysis applied to cystic fibrosis and glucose monitoring using a fully integrated wearable platform

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

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Flexible Sensing Electronics for Wearable/Attachable Health Monitoring

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Nanoparticle-Based Dressing: The Future of Wound Treatment?

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TRENDS IN BIOTECHNOLOGY (2017)

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Mussel-inspired hydrogel tissue adhesives for wound closure

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An Advanced Multifunctional Hydrogel-Based Dressing for Wound Monitoring and Drug Delivery

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A Micro-Pressure Sensing Method Based on the Micropatterned Electrodes Filled with the Microspheres

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Engineering a sprayable and elastic hydrogel adhesive with antimicrobial properties for wound healing

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Pharmaceutical Intermediate-Modified Gold Nanoparticles: Against Multidrug-Resistant Bacteria and Wound-Healing Application via an Electrospun Scaffold

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Elastin-like protein-hyaluronic acid (ELP-HA) hydrogels with decoupled mechanical and biochemical cues for cartilage regeneration

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Antibacterial anti-oxidant electroactive injectable hydrogel as self-healing wound dressing with hemostasis and adhesiveness for cutaneous wound healing

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Horseradish peroxidase supported on porous graphene as a novel sensing platform for detection of hydrogen peroxide in living cells sensitively

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Injectable Self-Healing Glucose-Responsive Hydrogels with pH-Regulated Mechanical Properties

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Polydopamine Nanoparticles Modulating Stimuli-Responsive PNIPAM Hydrogels with Cell/Tissue Adhesiveness

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PDMS-Based Elastomer Tuned Soft, Stretchable, and Sticky for Epidermal Electronics

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Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis

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Sweat-sensing patch for glucose monitoring and drug delivery

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Nature Reviews Endocrinology (2016)

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Toward Self-Powered Wearable Adhesive Skin Patch with Bendable Microneedle Array for Transdermal Drug Delivery

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A Flexible and Wearable Human Stress Monitoring Patch

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Injectable and Self-Healing Carbohydrate-Based Hydrogel for Cell Encapsulation

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Polyhydroxybutyrate-co-hydroxyvalerate structures loaded with adipose stem cells promote skin healing with reduced scarring

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Novel Biocompatible Polysaccharide-Based Self-Healing Hydrogel

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Transdermal patches: history, development and pharmacology

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Chitosan-hyaluronic acid/VEGF loaded fibrin nanoparticles composite sponges for enhancing angiogenesis in wounds

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A Conductive Self-Healing Hybrid Gel Enabled by Metal-Ligand Supramolecule and Nanostructured Conductive Polymer

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NANO LETTERS (2015)

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Soft, stretchable, fully implantable miniaturized optoelectronic systems for wireless optogenetics

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NATURE BIOTECHNOLOGY (2015)

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Toward Self-Healing Hydrogels Using One-Pot Thiol-Ene Click and Borax-Diol Chemistry

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A bio-inspired approach for in situ synthesis of tunable adhesive

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Pyroelectric materials and devices for energy harvesting applications

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Chitosan-based copper nanocomposite accelerates healing in excision wound model in rats

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Chitosan scaffold co-cultured with keratinocyte and fibroblast heals full thickness skin wounds in rabbit

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Wafer-scale design of lightweight and transparent electronics that wraps around hairs

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NATURE COMMUNICATIONS (2014)

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Electrospun polycaprolactone membranes incorporated with ZnO nanoparticles as skin substitutes with enhanced fibroblast proliferation and wound healing

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25 GHz Embedded-Gate Graphene Transistors with High-K Dielectrics on Extremely Flexible Plastic Sheets

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Laser Welding of Ruptured Intestinal Tissue Using Plasmonic Polypeptide Nanocomposite Solders

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Diels-Alder Mediated Controlled Release from a Poly(ethylene glycol) Based Hydrogel

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Active Silver Nanoparticles for Wound Healing

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)

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An ultra-lightweight design for imperceptible plastic electronics

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NATURE (2013)

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Self-healing polymers based on thermally reversible Diels-Alder chemistry

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POLYMER CHEMISTRY (2013)

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An Electronic Patch for Wearable Health Monitoring by Reflectance Pulse Oximetry

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IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS (2012)

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Poly(vinyl alcohol) Hydrogel Can Autonomously Self-Heal

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ACS MACRO LETTERS (2012)

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Dynamic Hydrogels with an Environmental Adaptive Self-Healing Ability and Dual Responsive Sol-Gel Transitions

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ACS MACRO LETTERS (2012)

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A thermally-stable self-mending polymer networked by Diels-Alder cycloaddition

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POLYMER (2011)

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Microelastic gradient gelatinous gels to induce cellular mechanotaxis

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Unique Cellular Interaction of Silver Nanoparticles: Size-Dependent Generation of Reactive Oxygen Species

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Strategies and Applications for Incorporating Physical and Chemical Signal Gradients in Tissue Engineering

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TISSUE ENGINEERING PART B-REVIEWS (2008)

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Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-γ and PTEN

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NATURE (2006)

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Luigi Galvani's path to animal electricity

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COMPTES RENDUS BIOLOGIES (2006)

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EGF loaded chitosan sponges as wound dressing material

EB Denkbas et al.

JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS (2003)

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