Dynamic m6A-ncRNAs association and their impact on cancer pathogenesis, immune regulation and therapeutic response

Several types of modifications have been proven to participate in the metabolism and processing of different RNA types, including non-coding RNAs (ncRNAs). N-6-methyladenosine (m6A) is a dynamic and reversible RNA modification that is closely involved in the ncRNA homeostasis, and serves as a crucial regulator for multiple cancer-associated signaling pathways. The ncRNAs usually regulate the epigenetic modification, mRNA transcrip-tion and other biological processes, displaying enormous roles in human cancers. In this review, we summarized the significant implications of m6A-ncRNA interaction in various types of can-cers. In particular, the interplay between m6A and ncRNAs in cancer pathogenesis and thera-peutic resistance are being widely recognized. We also discussed the relevance of m6A-ncRNA interaction in immune regulation, followed by the interference on cancer immunotherapeutic procedures. In addition, we briefly highlighted the computation tools that could identify the accurate features of m6A methylome among ncRNAs. In summary, this review would pave the way for a better understanding of the biological functions of m6A-ncRNA crosstalk in can-cer research and treatment.

Automated summary

This review summarizes the significant implications of the interaction between m6A and ncRNAs in various types of cancers, including cancer pathogenesis, therapeutic resistance, and immune regulation. It also highlights the relevance of this interaction in cancer immunotherapeutic procedures and the computation tools for m6A methylome identification among ncRNAs.