Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 21, Issue 23, Pages -Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d3ob00303e
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6,7-dihydroxycoumarin-5-carboxylates DHCou and 4-Me-DHCou were synthesized via a five-step route, including a propargyl-Claisen rearrangement as a key step. These compounds exhibit antibiofilm activity against Stapylococcus aureus and Candida albicans but lack the cytotoxic activity of parent 6,7-dihydroxycoumarines such as esculetin and 4-methylesculetin.
The 6,7-dihydroxycoumarin-5-carboxylates DHCou and 4-Me-DHCou have been synthesized via five-step route including a propargyl-Claisen rearrangement as key step. The compounds show antibiofilm activity against Stapylococcus aureus and Candida albicans but lack the cytotoxic activity of parent 6,7-dihydroxycoumarines such as esculetin and 4-methylesculetin.
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