Yca1 metacaspase: diverse functions determine how yeast live and let die

The Yca1 metacaspase was discovered due to its role in the regulation of apoptosis in Saccharomyces cerevisiae. However, the mechanisms that drive apoptosis in yeast remain poorly understood. Additionally, Yca1 and other metacaspase proteins have recently been recognized for their involvement in other cellular processes, including cellular proteostasis and cell cycle regulation. In this minireview, we outline recent findings on Yca1 that will enable the further study of metacaspase multifunctionality and novel apoptosis pathways in yeast and other nonmetazoans. In addition, we discuss advancements in high-throughput screening technologies that can be applied to answer complex questions surrounding the apoptotic and nonapoptotic functions of metacaspase proteins across a diverse range of species.

Automated summary

The discovery of Yca1 metacaspase's role in regulating apoptosis in Saccharomyces cerevisiae has shed light on understanding apoptotic mechanisms in yeast. Furthermore, recent studies have revealed the involvement of Yca1 and other metacaspase proteins in various cellular processes, such as cellular proteostasis and cell cycle regulation. This minireview presents recent findings on Yca1, which will facilitate further research on the multifunctionality of metacaspases and novel apoptosis pathways in yeast and other non-metazoans. Additionally, advancements in high-throughput screening technologies are discussed, offering potential solutions for exploring the apoptotic and nonapoptotic functions of metacaspase proteins across different species.