Utilization of methanol and ethanol for 3,3′-bis(indolyl)methane synthesis through activation of peroxymonosulfate over a copper catalyst

A greener and simple catalytic system is developed for the synthesis of biologically important 3,3 '-bisindolyl(methanes) (BIMs) using C1 and C2 alcohols as the carbon source for the bridging methylene group. The reaction occurred under very mild and environment friendly conditions without the requirement of any toxic solvents. The low cost CuO-peroxymonosulfate (CuO-PMS) system allows the reaction to be highly efficient, resulting in very good product yield.

Automated summary

A greener and simple catalytic system has been developed for the synthesis of biologically important 3,3'-bisindolyl(methanes) (BIMs) using C1 and C2 alcohols as the carbon source. The reaction takes place under very mild and environmentally friendly conditions without the need for any toxic solvents. The low-cost CuO-peroxymonosulfate (CuO-PMS) system allows for highly efficient reaction and results in high product yield.