Journal
CHEMICAL COMMUNICATIONS
Volume 59, Issue 35, Pages 5281-5284Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d3cc00963g
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In this article, a copper-catalyzed aerobic oxidation of primary alcohols to carboxylic acids with TEMPO and KHSO4 as co-catalysts is reported. The reaction demonstrates excellent substrate scope and functional group compatibility under mild conditions. Even sensitive chiral alcohols, chiral amino alcohols, and alcohol-containing steroid skeletons can be oxidized to the corresponding carboxylic acids or lactones without racemization.
Here, the first copper-catalyzed aerobic oxidation of primary alcohols to carboxylic acids with TEMPO and KHSO4 as the co-catalysts has been developed. The reaction exhibits excellent substrate scope and functional group compatibility under mild conditions. Even the very sensitive chiral alcohols, chiral amino alcohols, and alcohol-containing steroid skeletons may be oxidized to afford the corresponding carboxylic acids or lactones without racemization.
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