☆ 4.5 Review

Liver Damage and COVID-19: At Least a Two-Hit Story in Systematic Review

CURRENT ISSUES IN MOLECULAR BIOLOGY (2023)

Related references

Note: Only part of the references are listed.

Article Infectious Diseases

Efficacy and safety of azithromycin versus placebo to treat lower respiratory tract infections associated with low procalcitonin: a randomised, placebo-controlled, double-blind, non-inferiority trial

Ephraim L. Tsalik et al.

Summary: This study aimed to compare the efficacy and safety of azithromycin versus placebo for treating lower respiratory tract infections in patients with low procalcitonin concentrations. The results showed that after 5 days of treatment, azithromycin was not non-inferior to placebo in terms of clinical improvement. However, it is still unclear whether antibiotics are necessary for patients with lower respiratory tract infection and low procalcitonin concentrations.

LANCET INFECTIOUS DISEASES (2023)

Add to Collection

Article Pharmacology & Pharmacy

Systemic exposure to hydroxychloroquine and its relationship with outcome in severely ill COVID-19 patients in New York City

Alex K. Lyashchenko et al.

Summary: This study aimed to investigate the relationship between systemic exposure to hydroxychloroquine (HCQ) and its metabolite desethylhydroxychloroquine (DHCQ) and clinical outcome in severely ill COVID-19 patients. The results showed substantial variability in systemic exposure to HCQ and DHCQ, which was not clearly explained by renal or liver function or inflammatory state. Furthermore, systemic exposure did not correlate with intubation status, survival, or QTc prolongation. Therefore, this study adds to the growing body of evidence that oral HCQ does not alter the course of disease in COVID-19 patients.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2023)

Add to Collection

Article Medicine, Research & Experimental

Clinical characteristics of patients infected with novel coronavirus wild strain, Delta variant strain and Omicron variant strain in Quanzhou: A real-world study

Huatang Zhang et al.

Summary: This study aimed to investigate the clinical features of patients infected with novel coronavirus wild strains, Delta variant strains, and Omicron variant strains. The predominant clinical types were the novel coronavirus wild strain and Delta strain. Patients infected with the Omicron strain were mainly asymptomatic. Significant differences were found in various blood parameters among the three groups. Patients infected with the Omicron strain in Quanzhou presented with mild symptoms and had few comorbidities and a good prognosis, but the negative conversion time of the new coronavirus nucleic acid was still considerably long.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2023)

Add to Collection

Review Pharmacology & Pharmacy

Post-COVID-19 Gastro-Intestinal Disturbances

Emidio Scarpellini et al.

Summary: Background: Since the end of 2019, SARS-CoV-2 has caused the COVID-19 pandemic, and gastrointestinal (GI) symptoms during and after COVID-19 are receiving increasing attention. Methods: We review and comment on the prevalence, pathophysiology, and potential treatment options for GI disturbances in COVID-19. Results: Numerous reports show that a significant portion of COVID-19 patients experience GI symptoms both during and after the disease, with some experiencing symptoms for several months, even after vaccination. There is an ongoing debate regarding the association between GI symptoms and the outcome of COVID-19 patients. However, it is widely recognized that patients with chronic liver disease have a worse outcome. The similarities between GI symptoms and postinfectious functional dyspepsia and irritable bowel syndrome suggest that the gut microbiota may play a role. Preliminary reports and clinical trials have shown that modulating the gut microbiota could be an effective approach for treating and preventing COVID-19. Conclusion: GI symptoms have a significant impact on the natural course of both long-COVID-19 and non-long-COVID-19. Modulating the gut microbiota appears to be a promising target for disease treatment and prevention.

REVIEWS ON RECENT CLINICAL TRIALS (2023)

Add to Collection

Article Gastroenterology & Hepatology

Coronavirus Disease-2019 and Implications on the Liver

Patrick T. Campbell et al.

CLINICS IN LIVER DISEASE (2023)

Add to Collection

Article Gastroenterology & Hepatology

Human Gut Microbiota and Its Metabolites Impact Immune Responses in COVID-19 and Its Complications

Naoyoshi Nagata et al.

Summary: This study investigates the interrelationships among gut microbes, metabolites, and cytokines in COVID-19 and its complications, and validates the results with follow-up data. The results show multiple correlations between COVID-19-related microbes, gut metabolites, and inflammatory cytokine dynamics, especially in severe disease and pneumonia. The study also confirms the concordance of altered metabolites in COVID-19 with their corresponding microbial functional genes.

GASTROENTEROLOGY (2023)

Add to Collection

Article Pharmacology & Pharmacy

Safety profile of the lopinavir/ritonavir combination before and during the SARS-CoV-2 pandemic

Pauline Lory et al.

Summary: The use of lopinavir/ritonavir for COVID-19 treatment resulted in different adverse drug reactions compared to its usual indication for HIV. COVID-19 patients experienced more liver, heart, and kidney damage, whereas gastrointestinal and cutaneous reactions were more common before the pandemic.

THERAPIE (2023)

Add to Collection

Review Gastroenterology & Hepatology

Post-COVID-19 Cholangiopathy: A Systematic Review

Beshoy Yanny et al.

Summary: This study summarized 30 cases of post-COVID-19 cholangiopathy and analyzed their epidemiology, mechanism of action, histology, imaging findings, and outcomes. The results showed that post-COVID-19 cholangiopathy is a severe and progressive complication of COVID-19 infection, and more research is needed to understand its pathophysiology and optimal treatment approaches.

JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY (2023)

Add to Collection

Letter Hematology

Toxic myopathy and liver damage caused by concomitant therapy with remdesivir, atorvastatin, ezetimibe, and tacrolimus in a renal transplant patient with recently treated SARS-CoV-2 induced pneumonia: A case report

Zoran Sabljic et al.

THERAPEUTIC APHERESIS AND DIALYSIS (2022)

Add to Collection

Article Gastroenterology & Hepatology

Abnormal liver chemistries as a predictor of COVID-19 severity and clinical outcomes in hospitalized patients

Arunkumar Krishnan et al.

Summary: Abnormal liver chemistries are common in hospitalized COVID-19 patients and are closely related to disease severity and prognosis. Elevated levels of ALT, AST, ALP, and T-Bil can be used to assess risk and predict the need for advanced therapies in these patients.

WORLD JOURNAL OF GASTROENTEROLOGY (2022)

Add to Collection

Review Gastroenterology & Hepatology

Management of hepatitis B virus reactivation due to treatment of COVID-19

Terry Cheuk-Fung Yip et al.

Summary: There have been significant advancements in novel treatments for COVID-19, but some treatments may cause hepatitis B reactivation in patients with current or past HBV infection. The risk of HBVr exists, especially among those without antiviral prophylaxis, highlighting the importance of further research on the use of immunosuppressive therapies in COVID-19 patients with HBV infection.

HEPATOLOGY INTERNATIONAL (2022)

Add to Collection

Article Gastroenterology & Hepatology

Outcome of liver cancer patients with SARS-CoV-2 infection: An International, Multicentre, Cohort Study

Sergio Munoz-Martinez et al.

Summary: This study examines the outcomes and mortality risk of liver cancer patients infected with SARS-CoV-2, providing important insights into the impact of the virus on this population.

LIVER INTERNATIONAL (2022)

Add to Collection

Article Pharmacology & Pharmacy

Impact of SARS CoV-2 /COVID-19 infection on the course of advanced chronic liver disease and hepatocellular carcinoma

Monika Pazgan-Simon et al.

Summary: In patients with cirrhosis and hepatocellular carcinoma infected with SARS-CoV-2/COVID-19, the disease tends to have a more severe course, leading to exacerbation of liver disease. The main cause of death in this cohort was progression of liver disease complicated by liver failure.

PHARMACOLOGICAL REPORTS (2022)

Add to Collection

Review Gastroenterology & Hepatology

Current and future perspectives on acute-on-chronic liver failure: Challenges of transplantation, machine perfusion, and beyond

Bianca Della Guardia et al.

Summary: Acute-on-chronic liver failure (ACLF) is a common syndrome characterized by acute decompensation, organ failure, and high short-term mortality. Liver transplantation is an effective protective measure, and providing supportive treatment is crucial. However, more research and global discussion are needed to improve ACLF management.

WORLD JOURNAL OF GASTROENTEROLOGY (2022)

Add to Collection

Review Gastroenterology & Hepatology

Correlation between COVID-19 and hepatitis B: A systematic review

Yan-Fei He et al.

Summary: There is a certain association between COVID-19 and hepatitis B, but further research is needed to clarify the specific relationship.

WORLD JOURNAL OF GASTROENTEROLOGY (2022)

Add to Collection

Editorial Material Medicine, General & Internal

Acute Liver Failure and Acute-on-Chronic Liver Failure in COVID-19 Era

Tatsuo Kanda et al.

JOURNAL OF CLINICAL MEDICINE (2022)

Add to Collection

Review Nutrition & Dietetics

COVID-19 and Gut Injury

Sj Shen et al.

Summary: COVID-19-induced gut injury is a common symptom, and the mechanism is mainly due to the binding of SARS-CoV-2 to the ACE2 receptor in host cells. Antiviral drugs and monoclonal antibodies can reduce viral load and shorten the recovery time of the disease. Probiotics, ACE2 inhibitors, and nutrients are promising options for treating COVID-19-induced gut injury.

NUTRIENTS (2022)

Add to Collection

Article Infectious Diseases

Corticosteroid treatment in severe patients with SARS-CoV-2 and chronic HBV co-infection: a retrospective multicenter study

Mei Meng et al.

Summary: In patients with severe COVID-19/HBV co-infection, corticosteroid treatment may be associated with an increased risk of 28-day and in-hospital mortality. Additionally, corticosteroid treatment is also associated with delayed SARS-CoV-2 viral RNA clearance and increased risk of acute liver injury.

BMC INFECTIOUS DISEASES (2022)

Add to Collection

Article Medicine, Research & Experimental

Systems biology approach reveals a common molecular basis for COVID-19 and non-alcoholic fatty liver disease (NAFLD)

Shi-Tao Jiang et al.

Summary: This study identified 62 common DEGs for COVID-19 and NAFLD, extracted 10 hub genes, and constructed TF-DEGs, miRNAs-DEGs, and protein-drug interaction networks, demonstrating the complex regulatory relationships of common DEGs.

EUROPEAN JOURNAL OF MEDICAL RESEARCH (2022)

Add to Collection

Review Microbiology

Probiotics for immunomodulation in prevention against respiratory viral infections with special emphasis on COVID-19

T. Amrouche et al.

Summary: The COVID-19 pandemic has led to high mortality and economic crisis, with limited effectiveness of current drug-based therapies and vaccines. Therefore, there is an urgent need to find additional therapies that can prevent or improve symptoms in individuals infected with SARS-CoV-2 variants. This review examines the potential role of probiotics in promoting lung immune response to COVID-19 infection through gut-lung cross talk pathways, as well as the scientific information on SARS-CoV-2 and host antiviral immunity.

AIMS MICROBIOLOGY (2022)

Add to Collection

Article Emergency Medicine

Intensive care for seriously ill patients affected by novel coronavirus sars- CoV-2: Experience of the Crema Hospital, Italy

William Zuccon et al.

Summary: This study analyzed and shared the survival and mortality data of 54 consecutive ICU patients suffering from severe respiratory insufficiency due to viral SARS CoV 2 infection. The results indicated that surviving patients had better oxygen levels and blood gas analysis values compared to deceased patients. Additionally, the presence of multiple comorbidities and worsening pneumonia were shown to be adverse prognostic factors.

AMERICAN JOURNAL OF EMERGENCY MEDICINE (2021)

Add to Collection

Review Gastroenterology & Hepatology

COVID 19 and liver: An A-Z literature review

Marwa Ibrahim Metawea et al.

Summary: The COVID-19 pandemic has changed medical priorities, with a significant proportion of patients experiencing hepatic injury, particularly those with severe illness. This review focuses on the pathophysiology of COVID-19 induced liver injury, therapy related liver damage, and the effects of viral infection on preexisting liver diseases. Recommendations include more intensive surveillance and tailored therapeutic approaches for immunocompromised patients, advanced liver disease, hepatocellular carcinoma, and liver transplant patients. Despite limited studies, this overview provides insight on managing liver disease during COVID-19.

DIGESTIVE AND LIVER DISEASE (2021)

Add to Collection

Letter Gastroenterology & Hepatology

Correlation Between Liver Function Tests Abnormalities and Interleukin-6 Serum Levels in Patients With SARS-CoV-2 Infection

Francesca Romana Ponziani et al.

GASTROENTEROLOGY (2021)

Add to Collection

Review Gastroenterology & Hepatology

Pathophysiological mechanisms of liver injury in COVID-19

Alexander D. Nardo et al.

Summary: This review discusses the potential mechanisms of hepatic tropism of SARS-CoV-2 and acute, possibly long-term liver injury in COVID-19.

LIVER INTERNATIONAL (2021)

Add to Collection

Letter Gastroenterology & Hepatology

NAFLD is a predictor of liver injury in COVID-19 hospitalized patients but not of mortality, disease severity on the presentation or progression - The debate continues

Kamra Mushtaq et al.

JOURNAL OF HEPATOLOGY (2021)

Add to Collection

Review Virology

Liver injury in COVID-19: clinical features and treatment management

Dongdong Yu et al.

Summary: This article discusses the latest developments in the pathogenesis of liver injury caused by SARS-CoV-2, as well as the prone population and clinical characteristics of these patients, providing suggestions for clinical treatment.

VIROLOGY JOURNAL (2021)

Add to Collection

Review Gastroenterology & Hepatology

Liver injury in COVID-19: Detection, pathogenesis, and treatment

Yue Cai et al.

Summary: Liver injury is common in COVID-19 patients, potentially worsening the severity of the disease. However, the exact cause and mechanisms of COVID-related liver injury require further elucidation. This review aims to help clinicians develop better management strategies for patients with liver injury associated with COVID-19.

WORLD JOURNAL OF GASTROENTEROLOGY (2021)

Add to Collection

Review Medicine, General & Internal

Impact of COVID-19 on liver

Yu-Jang Su et al.

Summary: Liver injury is common after COVID-19 infection, with various mechanisms and symptoms. Different imaging findings and liver diseases may occur concomitantly, leading to poor outcomes.

WORLD JOURNAL OF CLINICAL CASES (2021)

Add to Collection

Review Medicine, General & Internal

COVID-19 infection and liver injury: Clinical features, biomarkers, potential mechanisms, treatment, and management challenges

Gholam Reza Sivandzadeh et al.

Summary: Liver impairment caused by COVID-19 infection may play a central role in severe clinical presentations; Patients with pre-existing liver diseases are at higher risk and require special considerations; Early detection and careful monitoring of liver damage is crucial in preventing liver failure in COVID-19 patients, especially those with pre-existing metabolic liver injury.

WORLD JOURNAL OF CLINICAL CASES (2021)

Add to Collection

Review Gastroenterology & Hepatology

Effect of COVID-19 on Pre-existing Liver disease: What Hepatologist Should Know?

Praveen Sharma et al.

Summary: COVID-19 patients may exhibit liver enzyme derangement in 15-55% of cases, with factors like advanced age, hypertension, diabetes, obesity, malignancy, and cardiovascular disease predisposing them to severe disease and hospitalization. Pre-existing liver diseases, particularly cirrhosis, can increase the severity and mortality of COVID-19. Immunosuppression should be reduced in patients with autoimmune liver disease, and certain medications like hydroxychloroquine and remdesivir have been found to be safe for patients with cirrhosis and COVID-19.

JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY (2021)

Add to Collection

Article Medicine, General & Internal

A Novel Coronavirus from Patients with Pneumonia in China, 2019

Na Zhu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Add to Collection

Article Medicine, General & Internal

Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia

Qun Li et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Add to Collection

Article Oncology

Clinical characteristics of COVID-19-infected cancer patients: a retrospective case study in three hospitals within Wuhan, China

L. Zhang et al.

ANNALS OF ONCOLOGY (2020)

Add to Collection

Editorial Material Toxicology

COVID-19 and drug-induced liver injury: a problem of plenty or a petty point?

Joost Boeckmans et al.

ARCHIVES OF TOXICOLOGY (2020)

Add to Collection

Letter Gastroenterology & Hepatology

Risk of severe illness from COVID-19 in patients with metabolic dysfunction-associated fatty liver disease and increased fibrosis scores

Giovanni Targher et al.

GUT (2020)

Add to Collection

Article Gastroenterology & Hepatology

Acute Liver Injury in COVID-19: Prevalence and Association with Clinical Outcomes in a Large US Cohort

Meaghan M. Phipps et al.

HEPATOLOGY (2020)

Add to Collection

Article Gastroenterology & Hepatology

COVID-19: Abnormal liver function tests

Qingxian Cai et al.

JOURNAL OF HEPATOLOGY (2020)

Add to Collection

Letter Gastroenterology & Hepatology

Non-alcoholic fatty liver diseases in patients with COVID-19: A retrospective study

Dong Ji et al.

JOURNAL OF HEPATOLOGY (2020)

Add to Collection

Article Virology

Clinical features and treatment of COVID-19 patients in northeast Chongqing

Suxin Wan et al.

JOURNAL OF MEDICAL VIROLOGY (2020)

Add to Collection

Review Gastroenterology & Hepatology

Liver diseases in COVID-19: Etiology, treatment and prognosis

Jian Wu et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2020)

Add to Collection

Letter Cell Biology

Recapitulation of SARS-CoV-2 infection and cholangiocyte damage with human liver ductal organoids

Bing Zhao et al.

PROTEIN & CELL (2020)

Add to Collection

Editorial Material Gastroenterology & Hepatology

COVID-19 and liver disease

Jian Sun et al.

LIVER INTERNATIONAL (2020)

Add to Collection

Letter Biochemistry & Molecular Biology

The proximal origin of SARS-CoV-2

Kristian G. Andersen et al.

NATURE MEDICINE (2020)

Add to Collection

Article Medicine, General & Internal

A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19

B. Cao et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Add to Collection

Review Gastroenterology & Hepatology

Systematic review with meta-analysis: liver manifestations and outcomes in COVID-19

Anand V. Kulkarni et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2020)

Add to Collection

Article Gastroenterology & Hepatology

Clinical Features of COVID-19-Related Liver Functional Abnormality

Zhenyu Fan et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2020)

Add to Collection

Article Gastroenterology & Hepatology

Pre-existing liver disease is associated with poor outcome in patients with SARS CoV2 infection; The APCOLIS Study (APASL COVID-19 Liver Injury Spectrum Study)

Shiv Kumar Sarin et al.

HEPATOLOGY INTERNATIONAL (2020)

Add to Collection

Letter Gastroenterology & Hepatology

Liver injury in remdesivir-treated COVID-19 patients

Rosa Zampino et al.

HEPATOLOGY INTERNATIONAL (2020)

Add to Collection

Review Medicine, General & Internal

Gut Microbiota and Liver Interaction through Immune System Cross-Talk: A Comprehensive Review at the Time of the SARS-CoV-2 Pandemic

Emidio Scarpellini et al.

JOURNAL OF CLINICAL MEDICINE (2020)

Add to Collection

Review Public, Environmental & Occupational Health

COVID-19: A Multidisciplinary Review

Nour Chams et al.

FRONTIERS IN PUBLIC HEALTH (2020)

Add to Collection

Article Medicine, General & Internal

The clinical manifestations and management of COVID-19-related liver injury

Tung-Hung Su et al.

JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION (2020)

Add to Collection

Article Gastroenterology & Hepatology

First case of drug-induced liver injury associated with the use of tocilizumab in a patient with COVID-19

Damir Muhovic et al.

LIVER INTERNATIONAL (2020)

Add to Collection

Editorial Material Endocrinology & Metabolism

Commentary: Obesity: The Achilles heel for COVID-19?

Giovanna Muscogiuri et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2020)

Add to Collection

Letter Endocrinology & Metabolism

Letter to the Editor: Obesity as a risk factor for greater severity of COVID-19 in patients with metabolic associated fatty liver disease

Kenneth I. Zheng et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2020)

Add to Collection

Article Immunology

Predictive factors of mortality in patients treated with tocilizumab for acute respiratory distress syndrome related to coronavirus disease 2019 (COVID-19)

Anne Lohse et al.

MICROBES AND INFECTION (2020)

Add to Collection

Article Multidisciplinary Sciences

Clinical characteristics of 82 cases of death from COVID-19

Bicheng Zhang et al.

PLOS ONE (2020)

Add to Collection

Letter Virology

Clinical Characteristics of Hospitalized Patients with SARS-CoV-2 and Hepatitis B Virus Co-infection

Xiaoping Chen et al.

VIROLOGICA SINICA (2020)

Add to Collection

Article Endocrinology & Metabolism

Pattern of liver function and clinical profile in COVID-19: A cross-sectional study of 91 patients

Abhishek Kumar et al.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2020)

Add to Collection

Review Biochemistry & Molecular Biology

COVID-19-associated gastrointestinal and liver injury: clinical features and potential mechanisms

Peijie Zhong et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Add to Collection

Review Immunology

How COVID-19 induces cytokine storm with high mortality

Shintaro Hojyo et al.

INFLAMMATION AND REGENERATION (2020)

Add to Collection

Review Gastroenterology & Hepatology

COVID-19 and Liver Dysfunction: Current Insights and Emergent Therapeutic Strategies

Gong Feng et al.

JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY (2020)

Add to Collection

Review Microbiology

Origin and evolution of pathogenic coronaviruses

Jie Cui et al.

NATURE REVIEWS MICROBIOLOGY (2019)

Add to Collection

Article Gastroenterology & Hepatology

Systematic review and meta-analysis of algorithms used to identify drug-induced liver injury (DILI) in health record databases

Eng Hooi Tan et al.

LIVER INTERNATIONAL (2018)

Add to Collection

Article Gastroenterology & Hepatology

Mechanisms of hepatic fibrogenesis

Ursula E. Lee et al.

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY (2011)

Add to Collection

Review Gastroenterology & Hepatology

Functional role of chemokines in liver disease models

Hacer Sahin et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2010)

Add to Collection

Review Medicine, General & Internal

The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration

Alessandro Liberati et al.

PLOS MEDICINE (2009)

Add to Collection

Article Medicine, General & Internal

A novel coronavirus associated with severe acute respiratory syndrome

TG Ksiazek et al.

NEW ENGLAND JOURNAL OF MEDICINE (2003)

Add to Collection

Article Gastroenterology & Hepatology

Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration

RF Schwabe et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2003)

Add to Collection

© Peeref 2019-2024. All rights reserved.