Journal
CLINICAL THERAPEUTICS
Volume 37, Issue 5, Pages 954-967Publisher
ELSEVIER
DOI: 10.1016/j.clinthera.2015.03.002
Keywords
brain; enteric nervous system; gut microbiota; immune system
Categories
Funding
- Science Foundation Ireland [07/CE/B1368, 12/RC/2273]
- Irish Health Research Board, Health Research Awards [HRA_POR/2011/23, HRA_POR/2012/32]
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Purpose: It is well established that mammals are so-called super-organisms that coexist with a complex microbiota. Growing evidence points to the delicacy of this host microbe interplay and how disruptive interventions could have lifelong consequences. The goal of this article was to provide insights into the potential role of the gut microbiota in coordinating the immune neuroendocrine cross-talk. Methods: Literature from a range of sources, including PubMed, Google Scholar, and MEDLINE, was searched to identify recent reports regarding the impact of the gut microbiota on the host immune and neuroendocrine systems in health and disease. Findings: The immune system and nervous system are in continuous communication to maintain a state of homeostasis. Significant gaps in knowledge remain regarding the effect of the gut microbiota in coordinating the immune nervous systems dialogue. Recent evidence from experimental animal models found that stimulation of subsets of immune cells by the gut microbiota, and the subsequent cross-talk between the immune cells and enteric neurons, may have a major impact on the host in health and disease. (C) 2015 Elsevier HS Journals, Inc. All rights reserved.
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