Electrochemical single-step N-acylation and S-cyclization synthesis of thiazolimide via radical process

The redox reaction (RR) plays an integral role in chemical processes (such as construction of structurally diverse molecules) and is incorporated into numerous organic electrochemical devices and systems. Researchers have worked to address the specifics of RRs via electrochemical molecular-coupling of carboxylic acids with different molecules. This work provides a new route to catalyst-class-dependent RR mechanisms and considers their corresponding feasibility relevant for their practical use in organic heterocyclic electrocatalytic systems. Our domino electrocatalytic redox reaction provides single-step N-acylation and S-cyclization synthesis of thiazolimide which has excellent tolerance of sensitive functional groups and overrides the possibility that thermal reactions occur. Thus affording a significant basis for the simple synthesis of thiazolimide.

Automated summary

The redox reaction is essential in various chemical processes and organic electrochemical devices. Scientists have used electrochemical molecular-coupling to study the mechanism of redox reactions and their practical application in organic electrocatalytic systems. Our research provides a new catalyst-dependent redox reaction mechanism and explores its feasibility in organic heterocyclic electrocatalytic systems, which enables the simple synthesis of thiazolimide with excellent functional group tolerance and without thermal reactions.