☆ 4.4 Review

Extracellular Vesicles (EVs) in Tumor Diagnosis and Therapy

TECHNOLOGY IN CANCER RESEARCH & TREATMENT (2023)

Related references

Note: Only part of the references are listed.

Review Cell Biology

Exosome: A novel neurotransmission modulator or non-canonical neurotransmitter?

Xiaohuan Xia et al.

Summary: This article reviews the role of exosomes in regulating neurotransmission. Exosomes can modulate synaptic activity and neural plasticity by transferring biomolecules. The article also proposes exosomes as novel neurotransmitters and discusses future directions in neurotransmission research.

AGEING RESEARCH REVIEWS (2022)

Add to Collection

Article Oncology

Induction of m6A methylation in adipocyte exosomal LncRNAs mediates myeloma drug resistance

Zhiming Wang et al.

Summary: This study elucidates an unexplored mechanism of how the adipocyte-rich microenvironment exacerbates therapeutic resistance in multiple myeloma (MM) and indicates a potential strategy to improve therapeutic efficacy by blocking the exosome-mediated cycle.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

Add to Collection

Article Gastroenterology & Hepatology

Exosome-delivered CD44v6/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment

Zhibo Xie et al.

Summary: This study revealed that PDAC-derived exosomes play a crucial role in modulating the liver microenvironment and promoting liver metastasis. The CD44v6/C1QBP complex delivered by exosomes to hepatic satellite cells leads to activation of insulin-like growth factor 1 signaling molecules and liver fibrosis. High expression of exosomal CD44v6 and C1QBP in PDAC patients is associated with liver metastasis.

GUT (2022)

Add to Collection

Review Oncology

Current Perspectives on the Unique Roles of Exosomes in Drug Resistance of Hepatocellular Carcinoma

Dongdong Xue et al.

Summary: This review summarizes and discusses the underlying relationship between exosomes and drug resistance in HCC, and suggests that exosomes may serve as candidate biomarkers for predicting and monitoring drug responses, as well as potential targets or vectors to reverse drug resistance in HCC.

JOURNAL OF HEPATOCELLULAR CARCINOMA (2022)

Add to Collection

Review Engineering, Biomedical

Extracellular Vesicles as an Advanced Delivery Biomaterial for Precision Cancer Immunotherapy

Shaobo Ruan et al.

Summary: Cancer immunotherapy has shown benefits in recent years, but novel targeting approaches and modulators are needed for broader patient populations. Extracellular vesicles (EVs) offer targeted immunity modulation and improved efficacy, with unique properties like surface markers and immunomodulatory functions. Future potential lies in EVs as a cancer immunotherapeutic biomaterial through reprogramming strategies and addressing unique challenges.

ADVANCED HEALTHCARE MATERIALS (2022)

Add to Collection

Review Andrology

Role and correlation of exosomes and integrins in bone metastasis of prostate cancer

Xinyu Geng et al.

Summary: Prostate cancer is a common tumor in the male genitourinary system, with bone metastasis being a significant complication. Exosomes and integrins have been found to be closely related to bone metastasis of prostate cancer, and their role in prevention, monitoring, and treatment is of great importance.

ANDROLOGIA (2022)

Add to Collection

Article Multidisciplinary Sciences

Organizing structural principles of the IL-17 ligand-receptor axis

Steven C. Wilson et al.

Summary: The IL-17 family of cytokines and receptors play crucial roles in host defence and inflammatory diseases. The IL-25-IL-17RB-IL-17RA ternary complex is a C2-symmetric complex, where IL-25 interacts with IL-17RB and two 'wing-like' IL-17RA co-receptors to initiate signal transduction through a 'tip-to-tip' geometry.

NATURE (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Structural insights into the lysophospholipid brain uptake mechanism and its inhibition by syncytin-2

Maria Martinez-Molledo et al.

Summary: This study reports the structure of the human MFSD2A-SYNC2 complex and reveals its importance in brain and placenta development and function. Additionally, SYNC2 acts as an inhibitor of MFSD2A transport, providing a new strategy for delivering therapeutic macromolecules across the blood-brain barrier.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2022)

Add to Collection

Article Biotechnology & Applied Microbiology

Biomimetic nanobubbles for triple-negative breast cancer targeted ultrasound molecular imaging

Natacha Jugniot et al.

Summary: TNBC is a highly heterogeneous breast cancer subtype with poor prognosis. In this study, we developed a targeted diagnostic agent using nanobubbles based on the TNBC cancer cell membrane. This agent showed increased extravasation and retention in a TNBC mouse model, and immunofluorescence analysis confirmed its presence in the tumor microenvironment. This approach has the potential to improve diagnosis and targeted drug delivery for TNBC, regardless of tumor tissue heterogeneity.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

Add to Collection

Article Multidisciplinary Sciences

SNARE assembly enlightened by cryo-EM structures of a synaptobrevin-Munc18-1-syntaxin-1 complex

Karolina P. Stepien et al.

Summary: This study reveals the binding mechanism of Munc18-1 to cross-linked syntaxin-1 and synaptobrevin through cryo-EM structures, and explores the mechanism of SNARE complex assembly. The results demonstrate that these interactions are critical for initiating SNARE complex assembly.

SCIENCE ADVANCES (2022)

Add to Collection

Article Cell & Tissue Engineering

MSC secreted extracellular vesicles carrying TGF-beta upregulate Smad 6 expression and promote the regrowth of neurons in spinal cord injured rats

Tianyu Han et al.

Summary: The study showed that EVs from MSCs can upregulate Smad 6 expression in NSCs by carrying TGF-beta, promoting neural differentiation. Early inhibition of TGF-beta did not increase neuron regrowth in spinal cord injury, but later treatment with TGF-beta inhibitor improved the neurological outcome by promoting neuron regrowth.

STEM CELL REVIEWS AND REPORTS (2022)

Add to Collection

Article Chemistry, Multidisciplinary

A Microfluidics-Based Scalable Approach to Generate Extracellular Vesicles with Enhanced Therapeutic MicroRNA Loading for Intranasal Delivery to Mouse Glioblastomas

Kai Wang et al.

Summary: A scalable microfluidic platform was developed to load therapeutic miRNAs and drugs into EVs while controlling their size, leading to improved treatment outcomes in orthotopic GBM mouse models. The engineered mpEVs demonstrated efficient delivery of miRNAs and drugs to GBM cells, resulting in tumor regression and increased survival rates in mice, showing potential for clinical translation in GBM therapy.

ACS NANO (2021)

Add to Collection

Article Engineering, Biomedical

M1 macrophage exosomes engineered to foster M1 polarization and target the IL-4 receptor inhibit tumor growth by reprogramming tumor-associated macrophages into M1-like macrophages

Gowri Rangaswamy Gunassekaran et al.

Summary: In this study, M1 macrophage-derived exosomes were engineered to reprogram TAMs into M1-like macrophages for inhibiting tumor growth. The results showed that systemic administration of these exosomes increased anti-tumor immunity more efficiently than untargeted and control peptide-labeled exosomes.

BIOMATERIALS (2021)

Add to Collection

Article Engineering, Environmental

Micro fluidics for extracellular vesicle separation and mimetic synthesis: Recent advances and future perspectives

Yingchao Meng et al.

Summary: Microfluidic technologies are gaining interest for their potential in fast and efficient extracellular vesicle processing, highlighting recent advances in EV separation and mimetics synthesis for drug delivery applications. The discussion also touches on the advantages and drawbacks of current technologies, as well as addressing future challenges and applications in the field.

CHEMICAL ENGINEERING JOURNAL (2021)

Add to Collection

Article Biochemical Research Methods

Modern isolation and separation techniques for extracellular vesicles

Thanaporn Liangsupree et al.

Summary: Extracellular vesicles (EVs) are crucial in cellular communication and regulating physiological and pathological processes. Modern isolation techniques are characterized by being time-efficient, easy to operate, and capable of providing EVs with suitable purity and integrity for various applications.

JOURNAL OF CHROMATOGRAPHY A (2021)

Add to Collection

Article Oncology

Exosomal ANGPTL1 attenuates colorectal cancer liver metastasis by regulating Kupffer cell secretion pattern and impeding MMP9 induced vascular leakiness

Kai Jiang et al.

Summary: Exosomal ANGPTL1 attenuated CRC liver metastasis and impeded vascular leakiness in the liver pre-metastatic niche by reprogramming Kupffer cells and decreasing MMP9 expression.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

Add to Collection

Article Multidisciplinary Sciences

Cryo-EM structure of the B cell co-receptor CD19 bound to the tetraspanin CD81

Katherine J. Susa et al.

Summary: The structure of the CD19-CD81 complex bound to a therapeutic antigen-binding fragment was determined by cryo-electron microscopy, revealing the contact interface between the ectodomains and the conformational changes of CD81 upon binding to CD19. This provides insights into the assembly of the CD19-CD81 complex and offers a basis for designing therapies for B cell dysfunction.

SCIENCE (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Ionising Radiation Promotes Invasive Potential of Breast Cancer Cells: The Role of Exosomes in the Process

Raheem Al-Abedi et al.

Summary: Exosomes play a crucial role in multidirectional communication between tumor cells and their microenvironment, potentially enhancing malignant tumor phenotypes. This study aimed to investigate the bystander effects of ionizing radiation on the invasive potential of MCF-7 breast cancer cells through exosome-mediated communication, highlighting alterations in miRNA and protein content as possible mechanisms for increased invasiveness.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Review Physiology

Integrin, Exosome and Kidney Disease

An-Ran Shen et al.

Summary: Integrins are transmembrane receptors that play essential roles in cellular adhesion, migration, communication, and signaling. Recent studies have shown that integrins are part of exosomal cargo and they are implicated in various pathophysiologic conditions, including kidney diseases such as fibrosis and glomerulosclerosis.

FRONTIERS IN PHYSIOLOGY (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells

Caleb R. Glassman et al.

Summary: The structural mechanism of receptor sharing used by IL-12 family cytokines can be utilized to tune the cytokine axis for therapeutics, as demonstrated by the design of IL-12 partial agonists that elicited anti-tumor immunity in vivo.

CELL (2021)

Add to Collection

Article Chemistry, Multidisciplinary

Natural or Synthetic RNA Delivery: A Stoichiometric Comparison of Extracellular Vesicles and Synthetic Nanoparticles

Daniel E. Murphy et al.

Summary: RNA therapeutics have great potential, but face challenges in delivery to target cells. Extracellular vesicles (EVs) have emerged as promising RNA delivery vehicles with significantly higher delivery efficiency compared to synthetic systems.

NANO LETTERS (2021)

Add to Collection

Article Multidisciplinary Sciences

Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes

Shirley Tremel et al.

Summary: The lipid phosphatidylinositol-3-phosphate (PI3P) acts as a regulator of endocytosis and autophagy, generated by two complexes containing the lipid kinase VPS34. Rab5 and Rab1a GTPases recruit and activate specific VPS34 complexes on membranes through unique binding interfaces, guiding them to distinct cellular locations. Insights into the recruitment and activation mechanisms of VPS34 complexes by specific Rab GTPases are provided through biochemical and structural analyses.

NATURE COMMUNICATIONS (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Enhancement of target toxin neutralization effect in vivo by PEGylation of multifunctionalized lipid nanoparticles

Hiroyuki Koide et al.

Summary: Protein-protein interactions involve weak interactions, in this study, we optimized PEG-modified MF-LNPs to increase their blood circulation time. PEGmix-MF-LNPs exhibited better blood circulation characteristics compared to PEG5k-MF-LNPs, with PEG5k and PEG2k representing PEG with molecular weights of 5000 and 2000, respectively.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

Add to Collection

Article Oncology

Extracellular vesicles-derived microRNA-222 promotes immune escape via interacting with ATF3 to regulate AKT1 transcription in colorectal cancer

Shiquan Li et al.

Summary: Immunotherapy has emerged as a novel approach for treating colorectal cancer, and this study demonstrated that miR-222 from MSC-EVs modulated posttranscriptional regulation to enhance AKT pathway and immune escape in CRC. The findings suggest that targeting miR-222 and ATF3 could be a potential therapeutic strategy for CRC.

BMC CANCER (2021)

Add to Collection

Article Oncology

Glioblastoma Cell-Derived lncRNA-Containing Exosomes Induce Microglia to Produce Complement C5, Promoting Chemotherapy Resistance

Ziwei Li et al.

Summary: This study found that lnc-TALC could be transmitted to tumor-associated macrophages (TAM) via exosomes, promoting M2 polarization and increasing resistance of brain tumors to TMZ chemotherapy. The results suggest that the interaction mediated by lnc-TALC between GBM cells and microglia can reduce the efficacy of chemotherapy, indicating potential combination therapy strategies to overcome drug resistance.

CANCER IMMUNOLOGY RESEARCH (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Role of Exosomes in Prostate Cancer Metastasis

Theresa Akoto et al.

Summary: Prostate cancer is a life-threatening disease among men globally, with metastasis being the major cause of mortality. Cell-to-cell communication plays a crucial role in the progression and metastasis of prostate cancer, with exosomes/extracellular vesicles demonstrating significant involvement in signaling pathways related to metastasis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Exosomes: Small EVs with Large Immunomodulatory Effect in Glioblastoma

Laura Benecke et al.

Summary: Glioblastomas, highly aggressive tumors with low survival rates, create an immunosuppressive microenvironment through the transportation of biomolecules by exosomes. Recent studies have shown the significant impact of tumor-derived exosomes on immune cells, highlighting their potential as diagnostic tools and therapeutic targets for aggressive tumor cells like glioblastomas. Exosomes serve as important instruments for molecular understanding of tumors given their structural and functional properties.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Bone marrow mesenchymal stem cells promote prostate cancer cell stemness via cell-cell contact to activate the Jagged1/Notch1 pathway

Ji-wen Cheng et al.

Summary: The study revealed that MSCs promoted the stemness of PCa cells through cell-cell contact, independent of the CCL5/CCR5 pathway, but through activation of the Jagged1/Notch1 pathway. Inhibition of Jagged1-Notch1 signaling significantly inhibited MSCs-induced stemness and tumorigenesis in PCa cells in vitro and in vivo, suggesting a potential therapeutic target for PCa treatment.

CELL AND BIOSCIENCE (2021)

Add to Collection

Article Multidisciplinary Sciences

Structural insights into integrin α5β1 opening by fibronectin ligand

Stephanie Schumacher et al.

Summary: The interaction mechanism between Integrin alpha(5)beta(1) and fibronectin was studied, revealing significant conformational changes upon complex formation. Additionally, the resting state of the integrin adopts an incompletely bent conformation, challenging the existing model.

SCIENCE ADVANCES (2021)

Add to Collection

Article Cell Biology

Structural and Functional Characterization of Fibronectin in Extracellular Vesicles From Hepatocytes

Xinlei Li et al.

Summary: Extracellular vesicles (EVs) are membrane-limited nanoparticles containing a complex molecular payload that can be taken up by other cells. This study found that fibronectin (FN1) is a component of hepatocyte-derived EVs facilitating their uptake by target cells, but it is not essential for EV-mediated anti-fibrotic activity in vivo.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Add to Collection

Review Cell Biology

Emerging Role of Exosomes in Liquid Biopsy for Monitoring Prostate Cancer Invasion and Metastasis

Zhengfan Gao et al.

Summary: Prostate cancer is the most common solid tumor in men, with different prognostic outcomes for local versus metastatic cases. Traditional diagnostic methods rely on tissue biopsy and PSA tests, but liquid biopsy using exosomal proteins and miRNAs show promise in tracking PCa progression and metastasis. These biomarkers could provide more comprehensive information and guide treatment options at all stages of PCa.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Add to Collection

Article Chemistry, Multidisciplinary

Camouflaged Hybrid Cancer Cell-Platelet Fusion Membrane Nanovesicles Deliver Therapeutic MicroRNAs to Presensitize Triple-Negative Breast Cancer to Doxorubicin

Yi Liu et al.

Summary: Camouflaged cell-membrane-based nanoparticles loaded with therapeutic miRNAs show promise in improving treatment outcomes for breast cancer. This strategy has the potential for clinical translation to enhance personalized therapy for breast cancer and other malignancies, by sensitizing tumor cells to chemotherapy and demonstrating site-specific accumulation at tumor sites.

ADVANCED FUNCTIONAL MATERIALS (2021)

Add to Collection

Article Cell Biology

Cancer derived exosomes induce macrophages immunosuppressive polarization to promote bladder cancer progression

Ziming Jiang et al.

Summary: The study revealed that exosomes released by bladder cancer cells can promote the immunosuppressive polarization of macrophages, facilitating tumor growth. This process is mediated by down-regulation of PTEN and activation of AKT/STAT3/6 signaling. Inhibiting the generation or secretion of exosomes can suppress the immunosuppressive transformation of macrophages, thereby inhibiting tumor growth.

CELL COMMUNICATION AND SIGNALING (2021)

Add to Collection

Review Oncology

Therapeutic roles of mesenchymal stem cell-derived extracellular vesicles in cancer

Zhijie Weng et al.

Summary: Extracellular vesicles (EVs) are essential regulators of intercellular communication enclosing various biomolecules, and MSC-derived EVs have shown potential applications in cancer treatment. However, challenges remain in translating MSC-derived EVs from bench to bedside.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Tumor-associated exosomes promote lung cancer metastasis through multiple mechanisms

Chunyang Jiang et al.

Summary: Exosomes play a crucial role in the communication between tumor cells and their microenvironment, especially in the development of lung cancer metastasis. Studies have shown that tumor-derived exosomes promote lung cancer via processes such as inducing epithelial-mesenchymal transition. Understanding these mechanisms provides researchers with new ideas to explore clinical applications for the diagnosis and treatment of lung cancer metastasis.

MOLECULAR CANCER (2021)

Add to Collection

Article Multidisciplinary Sciences

Structural mechanism of laminin recognition by integrin

Takao Arimori et al.

Summary: Recognition of laminin by integrin receptors mediates epithelial cell adhesion to basement membrane. The interface between laminin and integrin is composed of multiple binding sites on different subunits, with the gamma 1 chain of laminin playing a key role in bridging interactions between integrin alpha 6 and beta 1 subunits. The alpha 5 chain of laminin also enhances affinity and specificity by electrostatic interactions with the beta -propeller domain of integrin alpha 6.

NATURE COMMUNICATIONS (2021)

Add to Collection

Article Multidisciplinary Sciences

Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5

Hui Zhang et al.

Summary: The chemokine receptor CCR5 plays multiple roles in the immune system. The structures of G(i1) protein-coupled CCR5 with or without a chemokine bound, as well as the CCR5- chemokine MIP-1 alpha complex, offer insights into the distinct binding modes of the ligands and the mechanism of CCR5 activation.

NATURE COMMUNICATIONS (2021)

Add to Collection

Article Multidisciplinary Sciences

Structural basis of the activation of the CC chemokine receptor 5 by a chemokine agonist

Polina Isaikina et al.

Summary: The study reveals the structure and activation mechanism of CCR5, showing how chemokine agonists transmit activation signals through the receptor. It also finds differences in the activity relationship and activation mechanism between agonist and antagonist chemokines.

SCIENCE ADVANCES (2021)

Add to Collection

Review Cell Biology

Inhibition of extracellular vesicle pathway using neutral sphingomyelinase inhibitors as a neuroprotective treatment for brain injury

Asit Kumar et al.

Summary: Traumatic brain injury is a major cause of death and disability worldwide, leading to secondary neurodegenerative changes and cognitive dysfunction. Extracellular vesicles have potential as drug delivery vehicles and play a role in inflammatory responses following brain injury.

NEURAL REGENERATION RESEARCH (2021)

Add to Collection

Article Medicine, Research & Experimental

Transplantation of autologous extracellular vesicles for cancer-specific targeting

Alessandro Villa et al.

Summary: Research has shown that nano- and microsized extracellular vesicles (EVs) play a significant role in intercellular communication and can be used for targeted cancer therapy. By labeling EVs with indocyanine green (ICG) and tracking their distribution, it was found that nanoparticles with cancer tropism exist in the blood of colorectal cancer (CRC) patients. In mouse models, it was demonstrated that transplanted EVs were able to recognize tumors and deliver tumor-interfering molecules, indicating the therapeutic potential of autologous EVs for cancer treatment.

THERANOSTICS (2021)

Add to Collection

Article Cell Biology

Pancreatic cancer cell-derived exosomal microRNA-27a promotes angiogenesis of human microvascular endothelial cells in pancreatic cancer via BTG2

Dan Shang et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

Add to Collection

Review Oncology

Exosomes in triple negative breast cancer: Garbage disposals or Trojan horses?

Chia Yin Goh et al.

CANCER LETTERS (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Cryo-EM Reveals Integrin-Mediated TGF-β Activation without Release from Latent TGF-β

Melody G. Campbell et al.

CELL (2020)

Add to Collection

Review Biochemistry & Molecular Biology

The significance of exosomes in the development and treatment of hepatocellular carcinoma

Xin Li et al.

MOLECULAR CANCER (2020)

Add to Collection

Review Multidisciplinary Sciences

The biology, function, and biomedical applications of exosomes

Raghu Kalluri et al.

SCIENCE (2020)

Add to Collection

Article Biotechnology & Applied Microbiology

Engineered exosomes for targeted co-delivery of miR-21 inhibitor and chemotherapeutics to reverse drug resistance in colon cancer

Gaofeng Liang et al.

JOURNAL OF NANOBIOTECHNOLOGY (2020)

Add to Collection

Review Cell Biology

Tumor-derived exosomes in the regulation of macrophage polarization

Mirza S. Baig et al.

INFLAMMATION RESEARCH (2020)

Add to Collection

Review Immunology

Extracellular Vesicles in Glioblastoma Tumor Microenvironment

Anuroop Yekula et al.

FRONTIERS IN IMMUNOLOGY (2020)

Add to Collection

Article Multidisciplinary Sciences

A live cell reporter of exosome secretion and uptake reveals pathfinding behavior of migrating cells

Bong Hwan Sung et al.

NATURE COMMUNICATIONS (2020)

Add to Collection

Article Multidisciplinary Sciences

Structural insights into tetraspanin CD9 function

Rie Umeda et al.

NATURE COMMUNICATIONS (2020)

Add to Collection

Article Multidisciplinary Sciences

Syncytiotrophoblast extracellular microvesicle profiles in maternal circulation for noninvasive diagnosis of preeclampsia

Lisa Levine et al.

SCIENTIFIC REPORTS (2020)

Add to Collection

Review Immunology

Modulating Cytokine Production via Select Packaging and Secretion From Extracellular Vesicles

Betsy J. Barnes et al.

FRONTIERS IN IMMUNOLOGY (2020)

Add to Collection

Article Oncology

Tumor-derived exosomes facilitate tumor cells escape from drug therapy in clear cell renal cell carcinoma

Xiaogang Wang et al.

Translational Cancer Research (2020)

Add to Collection

Review Cardiac & Cardiovascular Systems

Native and bioengineered extracellular vesicles for cardiovascular therapeutics

Ricardo Cerqueira de Abreu et al.

NATURE REVIEWS CARDIOLOGY (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Arginase-1+Exosomes from Reprogrammed Macrophages Promote Glioblastoma Progression

Juliana H. Azambuja et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Add to Collection

Article Multidisciplinary Sciences

Structural basis of CXC chemokine receptor 2 activation and signalling

Kaiwen Liu et al.

NATURE (2020)

Add to Collection

Article Multidisciplinary Sciences

Structural basis for chemokine receptor CCR6 activation by the endogenous protein ligand CCL20

David Jonathan Wasilko et al.

NATURE COMMUNICATIONS (2020)

Add to Collection

Article Biology

The Sec1/Munc18 protein Vps45 holds the Qa-SNARE Tlg2 in an open conformation

Travis J. Eisemann et al.

ELIFE (2020)

Add to Collection

Article Multidisciplinary Sciences

Evaluation of immune and chemical precipitation methods for plasma exosome isolation

Tatiana Shtam et al.

PLOS ONE (2020)

Add to Collection

Review Cell Biology

Exosomes and breast cancer drug resistance

Xingli Dong et al.

CELL DEATH & DISEASE (2020)

Add to Collection

Review Biochemistry & Molecular Biology

Exosomes: key players in cancer and potential therapeutic strategy

Jie Dai et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Add to Collection

Review Biochemistry & Molecular Biology

Exosomes in cancer development, metastasis, and immunity

Lin Zhang et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2019)

Add to Collection

Article Oncology

Chemotherapy-Induced Extracellular Vesicle miRNAs Promote Breast Cancer Stemness by Targeting ONECUT2

Meng Shen et al.

CANCER RESEARCH (2019)

Add to Collection

Review Cell & Tissue Engineering

Manufacturing and characterization of extracellular vesicles from umbilical cord-derived mesenchymal stromal cells for clinical testing

Eva Rohde et al.

CYTOTHERAPY (2019)

Add to Collection

Review Biochemistry & Molecular Biology

Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance

Ladan Mashouri et al.

MOLECULAR CANCER (2019)

Add to Collection

Article Biochemistry & Molecular Biology

CAFs secreted exosomes promote metastasis and chemotherapy resistance by enhancing cell stemness and epithelial-mesenchymal transition in colorectal cancer

J. L. Hu et al.

MOLECULAR CANCER (2019)

Add to Collection

Review Biochemistry & Molecular Biology

Microvesicles and chemokines in tumor microenvironment: mediators of intercellular communications in tumor progression

Xiaojie Bian et al.

MOLECULAR CANCER (2019)

Add to Collection

Article Multidisciplinary Sciences

Mechanistic insights into the SNARE complex disassembly

Xuan Huang et al.

SCIENCE ADVANCES (2019)

Add to Collection

Article Oncology

Exosomal microRNAs derived from colon cancer cells promote tumor progression by suppressing fibroblast TP53 expression

Shunsuke Yoshii et al.

CANCER SCIENCE (2019)

Add to Collection

Review Cell Biology

Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis

Laura M. Doyle et al.

CELLS (2019)

Add to Collection

Article Cell Biology

Endosomal signalling via exosome surface TGFβ-1

Ganesh Vilas Shelke et al.

JOURNAL OF EXTRACELLULAR VESICLES (2019)

Add to Collection

Article Nanoscience & Nanotechnology

Smart cancer nanomedicine

Roy van der Meel et al.

NATURE NANOTECHNOLOGY (2019)

Add to Collection

Review Biochemical Research Methods

The Endosomal Escape of Nanoparticles: Toward More Efficient Cellular Delivery

Samuel A. Smith et al.

BIOCONJUGATE CHEMISTRY (2019)

Add to Collection

Article Oncology

Laminin 2-enriched extracellular vesicles of oral squamous cell carcinoma cells enhance in vitro lymphangiogenesis via integrin 3-dependent uptake by lymphatic endothelial cells

Ssu-Han Wang et al.

INTERNATIONAL JOURNAL OF CANCER (2019)

Add to Collection

Article Cell Biology

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

Mathilde Mathieu et al.

NATURE CELL BIOLOGY (2019)

Add to Collection

Article Biochemical Research Methods

Exosomes Derived from Human Primary and Metastatic Colorectal Cancer Cells Contribute to Functional Heterogeneity of Activated Fibroblasts by Reprogramming Their Proteome

Alin Rai et al.

PROTEOMICS (2019)

Add to Collection

Article Biochemical Research Methods

Urine-based liquid biopsy: non-invasive and sensitive AR-V7 detection in urinary EVs from patients with prostate cancer

Hyun-Kyung Woo et al.

LAB ON A CHIP (2019)

Add to Collection

Article Nanoscience & Nanotechnology

Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression

Fengmei Pi et al.

NATURE NANOTECHNOLOGY (2018)

Add to Collection

Article Chemistry, Multidisciplinary

Modification of Extracellular Vesicles by Fusion with Liposomes for the Design of Personalized Biogenic Drug Delivery Systems

Max Piffoux et al.

ACS NANO (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Exosomal miR-93 promotes proliferation and invasion in hepatocellular carcinoma by directly inhibiting TIMP2/TP53INP1/CDKN1A

Xiaofeng Xue et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Add to Collection

Article Oncology

Colorectal cancer cell-derived exosomes containing miR-10b regulate fibroblast cells via the PI3K/Akt pathway

Guangyao Dai et al.

BULLETIN DU CANCER (2018)

Add to Collection

Article Oncology

Hypoxic Tumor-Derived Exosomal miR-301a Mediates M2 Macrophage Polarization via PTEN/PI3K gamma to Promote Pancreatic Cancer Metastasis

Xiaofeng Wang et al.

CANCER RESEARCH (2018)

Add to Collection

Article Clinical Neurology

Exosomes as a biomarker platform for detecting epidermal growth factor receptor-positive high-grade gliomas

Sasidhar Venkata Manda et al.

JOURNAL OF NEUROSURGERY (2018)

Add to Collection

Review Biochemistry & Molecular Biology

Role of extracellular vesicles in glioma progression

Claudia Quezada et al.

MOLECULAR ASPECTS OF MEDICINE (2018)

Add to Collection

Article Multidisciplinary Sciences

Cancer-secreted hsa-miR-940 induces an osteoblastic phenotype in the bone metastatic microenvironment via targeting ARHGAP1 and FAM134A

Kyoko Hashimoto et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Add to Collection

Article Multidisciplinary Sciences

Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer

Tian Fang et al.

NATURE COMMUNICATIONS (2018)

Add to Collection

Article Multidisciplinary Sciences

A System of Cytokines Encapsulated in ExtraCellular Vesicles

Wendy Fitzgerald et al.

SCIENTIFIC REPORTS (2018)

Add to Collection

Review Medicine, Research & Experimental

Exosome Theranostics: Biology and Translational Medicine

Chuanjiang He et al.

THERANOSTICS (2018)

Add to Collection

Article Oncology

Exosomes Shuttle TREX1-Sensitive IFN-Stimulatory dsDNA from Irradiated Cancer Cells to DCs

Julie M. Diamond et al.

CANCER IMMUNOLOGY RESEARCH (2018)

Add to Collection

Article Immunology

Breast Cancer-Derived Exosomes Alter Macrophage Polarization via gp130/STAT3 Signaling

Sunyoung Ham et al.

FRONTIERS IN IMMUNOLOGY (2018)

Add to Collection

Review Immunology

Extracellular Vesicle Heterogeneity: Subpopulations, Isolation Techniques, and Diverse Functions in Cancer Progression

Eduard Willms et al.

FRONTIERS IN IMMUNOLOGY (2018)

Add to Collection

Article Oncology

Glioblastoma stem cell-derived exosomes induce M2 macrophages and PD-L1 expression on human monocytes

Konrad Gabrusiewicz et al.

ONCOIMMUNOLOGY (2018)

Add to Collection

Article Oncology

Exosomal transfer of miR-151a enhances chemosensitivity to temozolomide in drug-resistant glioblastoma

Ailiang Zeng et al.

CANCER LETTERS (2018)

Add to Collection

Article Cell Biology

Exosomal miR-27a Derived from Gastric Cancer Cells Regulates the Transformation of Fibroblasts into Cancer-Associated Fibroblasts

Jingya Wang et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

Add to Collection

Article Oncology

Circular RNA IARS (circ-IARS) secreted by pancreatic cancer cells and located within exosomes regulates endothelial monolayer permeability to promote tumor metastasis

Jie Li et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2018)

Add to Collection

Article Multidisciplinary Sciences

Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

Gang Chen et al.

NATURE (2018)

Add to Collection

Article Cell Biology

Exosomal miR-21-5p derived from gastric cancer promotes peritoneal metastasis via mesothelial-to-mesenchymal transition

Qiang Li et al.

CELL DEATH & DISEASE (2018)

Add to Collection

Article Oncology

Hepatocellular carcinoma-derived exosomal miRNA-21 contributes to tumor progression by converting hepatocyte stellate cells to cancer-associated fibroblasts

Yuan Zhou et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2018)

Add to Collection

Article Multidisciplinary Sciences

Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis

Zhicheng Zeng et al.

NATURE COMMUNICATIONS (2018)

Add to Collection

Article Multidisciplinary Sciences

Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix

A. E. Yuzhalin et al.

NATURE COMMUNICATIONS (2018)

Add to Collection

Article Cell Biology

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Clotilde Thery et al.

JOURNAL OF EXTRACELLULAR VESICLES (2018)

Add to Collection

Article Cell Biology

Tumor-Secreted Exosomal miR-222 Promotes Tumor Progression via Regulating P27 Expression and Re-Localization in Pancreatic Cancer

Zhonghu Li et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

Add to Collection

Review Biochemistry & Molecular Biology

Current knowledge on exosome biogenesis and release

Nina Pettersen Hessvik et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2018)

Add to Collection

Letter Oncology

CLL-cell-mediated MDSC induction by exosomal miR-155 transfer is disrupted by vitamin D

H. Bruns et al.

LEUKEMIA (2017)

Add to Collection

Article Urology & Nephrology

The Detection of Androgen Receptor Splice Variant 7 in Plasma-derived Exosomal RNA Strongly Predicts Resistance to Hormonal Therapy in Metastatic Prostate Cancer Patients

Marzia Del Re et al.

EUROPEAN UROLOGY (2017)

Add to Collection

Article Oncology

Exosomes-mediated transfer of long noncoding RNA ZFAS1 promotes gastric cancer progression

Lei Pan et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2017)

Add to Collection

Article Immunology

DNA-Containing Exosomes Derived from Cancer Cells Treated with Topotecan Activate a STING- Dependent Pathway and Reinforce Antitumor Immunity

Yuichi Kitai et al.

JOURNAL OF IMMUNOLOGY (2017)

Add to Collection

Article Multidisciplinary Sciences

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

Sushrut Kamerkar et al.

NATURE (2017)

Add to Collection

Article Multidisciplinary Sciences

Force interacts with macromolecular structure in activation of TGF-β

Xianchi Dong et al.

NATURE (2017)

Add to Collection

Article Oncology

Exosomes Derived From Hypoxic Colorectal Cancer Cells Promote Angiogenesis Through Wnt4-Induced β-Catenin Signaling in Endothelial Cells

Zhe Huang et al.

ONCOLOGY RESEARCH (2017)

Add to Collection

Article Multidisciplinary Sciences

Structure of human nSMase2 reveals an interdomain allosteric activation mechanism for ceramide generation

Michael V. Airola et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Add to Collection

Article Cell & Tissue Engineering

UBR2 Enriched in p53 Deficient Mouse Bone Marrow Mesenchymal Stem Cell-Exosome Promoted Gastric Cancer Progression via Wnt/β-Catenin Pathway

Jiahui Mao et al.

STEM CELLS (2017)

Add to Collection

Article Biochemistry & Molecular Biology

Structure of the Full-length VEGFR-1 Extracellular Domain in Complex with VEGF-A

Sandra Markovic-Mueller et al.

STRUCTURE (2017)

Add to Collection

Article Multidisciplinary Sciences

Exosome-delivered EGFR regulates liver microenvironment to promote gastric cancer liver metastasis

Haiyang Zhang et al.

NATURE COMMUNICATIONS (2017)

Add to Collection

Article

Breast cancer cell-derived exosomes and macrophage polarization are associated with lymph node metastasis

Yin Ji Piao et al.

Oncotarget (2017)

Add to Collection

Review Oncology

Treatment of renal cell carcinoma: Current status and future directions

Pedro C. Barata et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2017)

Add to Collection

Article Chemistry, Multidisciplinary

Combining Machine Learning and Nanofluidic Technology To Diagnose Pancreatic Cancer Using Exosomes

Jina Ko et al.

ACS NANO (2017)

Add to Collection

Article Oncology

Myoferlin plays a key role in VEGFA secretion and impacts tumor-associated angiogenesis in human pancreas cancer

Karim Fahmy et al.

INTERNATIONAL JOURNAL OF CANCER (2016)

Add to Collection

Article Oncology

Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC

Benjamin Besse et al.

ONCOIMMUNOLOGY (2016)

Add to Collection

Article Oncology

Exosome-Transmitted lncARSR Promotes Sunitinib Resistance in Renal Cancer by Acting as a Competing Endogenous RNA

Le Qu et al.

CANCER CELL (2016)

Add to Collection

Article Biochemistry & Molecular Biology

Crystal Structure of a Full-Length Human Tetraspanin Reveals a Cholesterol-Binding Pocket

Brandon Zimmerman et al.

CELL (2016)

Add to Collection

Article Biochemistry & Molecular Biology

The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity

Toshiro Moroishi et al.

CELL (2016)

Add to Collection

Article Chemistry, Multidisciplinary

PEGylated and targeted extracellular vesicles display enhanced cell specificity and circulation time

S. A. A. Kooijmans et al.

JOURNAL OF CONTROLLED RELEASE (2016)

Add to Collection

Article Oncology

CD44v6-competent tumor exosomes promote motility, invasion and cancer-initiating cell marker expression in pancreatic and colorectal cancer cells

Zhe Wang et al.

ONCOTARGET (2016)

Add to Collection

Article Oncology

A Novel Urine Exosome Gene Expression Assay to Predict High-grade Prostate Cancer at Initial Biopsy

James McKiernan et al.

JAMA ONCOLOGY (2016)

Add to Collection

Article Hematology

Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts

Jerome Paggetti et al.

BLOOD (2015)

Add to Collection

Article Urology & Nephrology

Exosomal miR-1290 and miR-375 as Prognostic Markers in Castration-resistant Prostate Cancer

Xiaoyi Huang et al.

EUROPEAN UROLOGY (2015)

Add to Collection

Review Immunology

Regulatory B Cells: Origin, Phenotype, and Function

Elizabeth C. Rosser et al.

IMMUNITY (2015)

Add to Collection

Article Oncology

Exosomes derived from miR-122-modified adipose tissue-derived MSCs increase chemosensitivity of hepatocellular carcinoma

Guohua Lou et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2015)

Add to Collection

Article Biotechnology & Applied Microbiology

The non-targeted effects of radiation are perpetuated by exosomes

Ammar Al-Mayah et al.

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2015)

Add to Collection

Article Multidisciplinary Sciences

Mechanistic insights into the recycling machine of the SNARE complex

Minglei Zhao et al.

NATURE (2015)

Add to Collection

Article Multidisciplinary Sciences

Tumour exosome integrins determine organotropic metastasis

Ayuko Hoshino et al.

NATURE (2015)

Add to Collection

Article Multidisciplinary Sciences

Glypican-1 identifies cancer exosomes and detects early pancreatic cancer

Sonia A. Melo et al.

NATURE (2015)

Add to Collection

Article Cell Biology

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

Bruno Costa-Silva et al.

NATURE CELL BIOLOGY (2015)

Add to Collection

Article Multidisciplinary Sciences

CLL Exosomes Modulate the Transcriptome and Behaviour of Recipient Stromal Cells and Are Selectively Enriched in miR-202-3p

Mosavar Farahani et al.

PLOS ONE (2015)

Add to Collection

Article Multidisciplinary Sciences

Structure and membrane remodeling activity of ESCRT-III helical polymers

John McCullough et al.

SCIENCE (2015)

Add to Collection

Article Multidisciplinary Sciences

MEMBRANE FUSION A direct role for the Sec1/Munc18-family protein Vps33 as a template for SNARE assembly

Richard W. Baker et al.

SCIENCE (2015)

Add to Collection

Article Oncology

Exosomal levels of miRNA-21 from cerebrospinal fluids associated with poor prognosis and tumor recurrence of glioma patients

Rui Shi et al.

ONCOTARGET (2015)

Add to Collection

Article Oncology

Identification of prostate cancer biomarkers in urinary exosomes

Anders Overbye et al.

ONCOTARGET (2015)

Add to Collection

Article Oncology

Urothelial cells undergo epithelial-to-mesenchymal transition after exposure to muscle invasive bladder cancer exosomes

C A Franzen et al.

Oncogenesis (2015)

Add to Collection

Article Oncology

Increasing glioma-associated monocytes leads to increased intratumoral and systemic myeloid-derived suppressor cells in a murine model

Michael Chae et al.

NEURO-ONCOLOGY (2015)

Add to Collection

Article Oncology

Plasma long noncoding RNA protected by exosomes as a potential stable biomarker for gastric cancer

Qier Li et al.

TUMOR BIOLOGY (2015)

Add to Collection

Article Cell Biology

Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting

Oscar P. B. Wiklander et al.

JOURNAL OF EXTRACELLULAR VESICLES (2015)

Add to Collection

Article Cell Biology

Optimized exosome isolation protocol for cell culture supernatant and human plasma

Richard J. Lobb et al.

JOURNAL OF EXTRACELLULAR VESICLES (2015)

Add to Collection

Article Biochemistry & Molecular Biology

Syncytin proteins incorporated in placenta exosomes are important for cell uptake and show variation in abundance in serum exosomes from patients with preeclampsia

Amandine Vargas et al.

FASEB JOURNAL (2014)

Add to Collection

Article Biology

Analysis of the RNA content of the exosomes derived from blood serum and urine and its potential as biomarkers

Mu Li et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2014)

Add to Collection

Review Reproductive Biology

Exosomes: an overview of biogenesis, composition and role in ovarian cancer

Allison Beach et al.

JOURNAL OF OVARIAN RESEARCH (2014)

Add to Collection

Article Immunology

Plasma exosomes as markers of therapeutic response in patients with acute myeloic leukemia

Chang-Sook Hong et al.

FRONTIERS IN IMMUNOLOGY (2014)

Add to Collection

Review Immunology

Tetraspanins in extracellular vesicle formation and function

Zoraida Andreu et al.

FRONTIERS IN IMMUNOLOGY (2014)

Add to Collection

Review Cell Biology

Routes and mechanisms of extracellular vesicle uptake

Laura Ann Mulcahy et al.

JOURNAL OF EXTRACELLULAR VESICLES (2014)

Add to Collection

Review Immunology

Regulation of immune responses by extracellular vesicles

Paul D. Robbins et al.

NATURE REVIEWS IMMUNOLOGY (2014)

Add to Collection

Article Oncology

Exosome derived from epigallocatechin gallate treated breast cancer cells suppresses tumor growth by inhibiting tumor-associated macrophage infiltration and M2 polarization

Ji-Young Jang et al.

BMC CANCER (2013)

Add to Collection

Article Oncology

Clinical impact of serum exosomal microRNA-21 as a clinical biomarker in human esophageal squamous cell carcinoma

Youhei Tanaka et al.

CANCER (2013)

Add to Collection

Article Oncology

Changes in circulating microRNA levels associated with prostate cancer

R. J. Bryant et al.

BRITISH JOURNAL OF CANCER (2012)

Add to Collection

Article Oncology

Analysis of exosome release and its prognostic value in human colorectal cancer

J. Silva et al.

GENES CHROMOSOMES & CANCER (2012)

Add to Collection

Article Medicine, Research & Experimental

Circulating miR-378 and miR-451 in serum are potential biomarkers for renal cell carcinoma

Martina Redova et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2012)

Add to Collection

Editorial Material Cell Biology

Get on the exosome bus with ALIX

James H. Hurley et al.

NATURE CELL BIOLOGY (2012)

Add to Collection

Article Multidisciplinary Sciences

Plasma-Derived Exosomal Survivin, a Plausible Biomarker for Early Detection of Prostate Cancer

Salma Khan et al.

PLOS ONE (2012)

Add to Collection

Article Oncology

Carcinoma origin dictates differential skewing of monocyte function

Marijn Bogels et al.

ONCOIMMUNOLOGY (2012)

Add to Collection

Editorial Material Biotechnology & Applied Microbiology

SiRNA delivery with exosome nanoparticles

Jasper G. van den Boorn et al.

NATURE BIOTECHNOLOGY (2011)

Add to Collection

Article Multidisciplinary Sciences

Multiple recognition assay reveals prostasomes as promising plasma biomarkers for prostate cancer

Gholamreza Tavoosidana et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Add to Collection

Article Biochemical Research Methods

The 12th Human Liver Proteome Project (HLPP) Workshop, September 2010, Sydney, Australia

Xueli Zhang et al.

PROTEOMICS (2011)

Add to Collection

Article Cell Biology

Integrin Structure, Activation, and Interactions

Iain D. Campbell et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2011)

Add to Collection

Article Oncology

Claudin-containing exosomes in the peripheral circulation of women with ovarian cancer

Jianghong Li et al.

BMC CANCER (2009)

Add to Collection

Article Oncology

Prostate cancer-derived urine exosomes: a novel approach to biomarkers for prostate cancer

J. Nilsson et al.

BRITISH JOURNAL OF CANCER (2009)

Add to Collection

Article Gastroenterology & Hepatology

Gastric cancer exosomes promote tumour cell proliferation through PI3K/Akt and MAPK/ERK activation

J. -L. Qu et al.

DIGESTIVE AND LIVER DISEASE (2009)

Add to Collection

Review Oncology

Tetraspanins: push and pull in suppressing and promoting metastasis

Margot Zoeller

NATURE REVIEWS CANCER (2009)

Add to Collection

Article Immunology

Re-educating tumor-associated macrophages by targeting NF-κB

Thorsten Hagemann et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2008)

Add to Collection

Article Multidisciplinary Sciences

Circulating microRNAs as stable blood-based markers for cancer detection

Patrick S. Mitchell et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Add to Collection

Article Biochemistry & Molecular Biology

Elucidation of Rab27 Recruitment by Its Effectors: Structure of Rab27a Bound to Exophilin4/Slp2-a

Leonard M. G. Chavas et al.

STRUCTURE (2008)

Add to Collection

Article Immunology

MHC class II+ exosomes in plasma suppress inflammation in an antigen-specific and fas Ligand/Fas-Dependent manner

Seon Hee Kim et al.

JOURNAL OF IMMUNOLOGY (2007)

Add to Collection

Article Biochemistry & Molecular Biology

Structural and biochemical studies of ALIX/AIP1 and its role in retrovirus budding

Robert D. Fisher et al.

CELL (2007)

Add to Collection

Article Medicine, Research & Experimental

Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes:: results of thefirst phase I clinical trial

B Escudier et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2005)

Add to Collection

Article Medicine, Research & Experimental

A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer

MA Morse et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2005)

Add to Collection

Article Multidisciplinary Sciences

Hexameric structure and assembly of the interleukin-6/IL-6 α-receptor/gp130 complex

MJ Boulanger et al.

SCIENCE (2003)

Add to Collection

Article Gastroenterology & Hepatology

Intestinal epithelial cells secrete exosome-like vesicles

G van Niel et al.

GASTROENTEROLOGY (2001)

Add to Collection

Article Immunology

Proteomic analysis of dendritic cell-derived exosomes:: A secreted subcellular compartment distinct from apoptotic vesicles

C Théry et al.

JOURNAL OF IMMUNOLOGY (2001)

Add to Collection

Article Multidisciplinary Sciences

Three-dimensional structure of the neuronal-Sec1-syntaxin 1a complex

KMS Misura et al.

NATURE (2000)

Add to Collection

© Peeref 2019-2024. All rights reserved.