Exploring the Conformational Equilibrium of Mefenamic Acid Released from Silica Aerogels via NMR Analysis

This study examines the influence of mefenamic acid on the physical and chemical properties of silica aerogels, as well as its effect on the sorption characteristics of the composite material. Solid state magic angle spinning nuclear magnetic resonance (MAS NMR) and high-pressure C-13 NMR kinetic studies were conducted to identify the presence of mefenamic acid and measure the kinetic rates of CO2 sorption. Additionally, a high-pressure T-1-T-2 relaxation-relaxation correlation spectroscopy (RRCOSY) study was conducted to estimate the relative amount of mefenamic acid in the aerogel's pores, and a high-pressure nuclear Overhauser effect spectoscopy (NOESY) study was conducted to investigate the conformational preference of mefenamic acid released from the aerogel. The results indicate that mefenamic acid is affected by the chemical environment of the aerogel, altering the ratio of mefenamic acid conformers from 75% to 25% in its absence to 22% to 78% in the presence of aerogel.

Automated summary

This study investigates the impact of mefenamic acid on the physical and chemical properties of silica aerogels, as well as its influence on the sorption characteristics of the composite material. Through solid state magic angle spinning nuclear magnetic resonance (MAS NMR) and high-pressure C-13 NMR kinetic studies, the presence of mefenamic acid was identified and the kinetic rates of CO2 sorption were measured. Additionally, high-pressure T-1-T-2 relaxation-relaxation correlation spectroscopy (RRCOSY) and high-pressure nuclear Overhauser effect spectroscopy (NOESY) studies were conducted to estimate the relative amount of mefenamic acid in the aerogel's pores and investigate its conformational preference when released from the aerogel.