Toward Practical Integration of Omic and Imaging Data in Co-Clinical Trials

Article Multidisciplinary Sciences

Identifying biomarkers of differential chemotherapy response in TNBC patient-derived xenografts with a CTD/WGCNA approach

Varduhi Petrosyan et al.

Summary: By using TNBC PDXs, we identified biomarkers of response to docetaxel and carboplatin, which showed predictive ability in both PDX datasets and clinical datasets, indicating their potential translational application.

ISCIENCE (2023)

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Article Biotechnology & Applied Microbiology

The EurOPDX Data Portal: an open platform for patient-derived cancer xenograft data sharing and visualization

Zdenka Dudova et al.

Summary: This article introduces the EurOPDX Data Portal, a unified platform that combines the European model catalog and molecular data analysis function. The Portal provides researchers with collaborative research PDX mice models and displays the molecular features and treatment research data of these models.

BMC GENOMICS (2022)

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Article Cell Biology

Genomic and epigenomic BRCA alterations predict adaptive resistance and response to platinum-based therapy in patients with triple-negative breast and ovarian carcinomas

Francesca Menghi et al.

Summary: Research found that triple-negative breast cancer (TNBC) and ovarian carcinomas (OvCas) with BRCA1 promoter methylation (BRCA1meth) respond poorly to alkylating agents compared to those with BRCA1 and BRCA2 mutations (BRCAmut). Despite similar downstream genomic mutational signatures, BRCA1meth is uniformly associated with poor outcomes and exhibits adaptability to genotoxin exposure through reversal of promoter methylation.

SCIENCE TRANSLATIONAL MEDICINE (2022)

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Article Biochemistry & Molecular Biology

PDXNet portal: patient-derived Xenograft model, data, workflow and tool discovery

Soner Koc et al.

Summary: We have created the PDXNet portal to centralize access to the consortium resources, facilitate collaboration among researchers, and provide easy access to the data. The portal includes different sections for resources, analysis results, metrics, protocols, and training materials. Currently, it contains information and data resources from 334 new models across 33 cancer types. The portal is continuously updated and is an important tool for the cancer research community.

NAR CANCER (2022)

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Article Oncology

A human breast cancer-derived xenograft and organoid platform for drug discovery and precision oncology

Katrin P. Guillen et al.

Summary: Models that recapitulate the complexity of human tumors are urgently needed to develop more effective cancer therapies. In this study, researchers report a bank of human patient-derived xenografts and organoid cultures from breast cancers that are resistant to treatment and have metastasized. They demonstrate the feasibility and cost-effectiveness of using these models for drug screening, and also show the potential of applying precision oncology in real-time clinical care. The study provides valuable methods and resources for functional precision medicine and drug development for human breast cancer.

NATURE CANCER (2022)

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Article Genetics & Heredity

Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

Xing Yi Woo et al.

Summary: The analysis of copy number alterations in patient-derived xenografts (PDXs) and matched patient tumor samples reveals strong conservation of copy number alterations from patient tumors through late-passage PDXs, without systematic evolution driven by the mouse host. This suggests that PDX models are accurate in representing human cancer and that the mouse host does not significantly impact the copy number alterations during tumor evolution within the PDX model.

NATURE GENETICS (2021)

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Article Oncology

Multiethnic PDX models predict a possible immune signature associated with TNBC of African ancestry

Evelyn M. Jiagge et al.

Summary: This study aimed to investigate the biological differences of triple-negative breast cancer (TNBC) in women of African ancestry and Caucasian women by comparing the gene expression of breast cancer stem cells (BCSC). The results showed that BCSC in tumors from women of African ancestry exhibited enrichment in immune-related genes and processes, highlighting potential drug targets for TNBC treatment.

BREAST CANCER RESEARCH AND TREATMENT (2021)

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Article Oncology

Patient-Derived Xenograft Engraftment and Breast Cancer Outcomes in a Prospective Neoadjuvant Study (BEAUTY)

Judy C. Boughey et al.

Summary: In this study, it was found that PDX engraftment did not predict breast cancer recurrence in patients receiving standard neoadjuvant chemotherapy, while patients with PDX engraftment after treatment had a higher incidence of breast events, although not statistically significant. Further research is needed to determine the prognostic value of PDX engraftment in the treatment-resistant setting for cancer recurrence.

CLINICAL CANCER RESEARCH (2021)

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Article Multidisciplinary Sciences

Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidatesfor targeted treatment

Hua Sun et al.

Summary: This study presents genomic landscapes of 536 patient-derived xenograft (PDX) models across 25 cancer types, providing insights into their molecular features and suitability for clinical trials. PDXs typically have higher purity than human tumors and are useful for investigating dynamic driver events and molecular properties, making them valuable tools in cancer research and drug development.

NATURE COMMUNICATIONS (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging