Visual Evoked Potentials for the Detection of Diabetic Retinal Neuropathy

Visual evoked potentials (VEP) are visually evoked signals that extract electroencephalographic activity in the visual cortex that can detect retinal ganglion cells, optic nerves, chiasmal and retrochiasmal dysfunction, including optic radiations, and the occipital cortex. Because diabetes causes diabetic retinopathy due to microangiopathy and neuropathy due to metabolic abnormalities and intraneural blood flow disorders, assessment of diabetic visual pathway impairment using VEP has been attempted. In this review, evidence on the attempts to assess the visual pathway dysfunction due to abnormal blood glucose levels using VEP is presented. Previous studies have provided significant evidence that VEP can functionally detect antecedent neuropathy before fundus examination. The detailed correlations between VEP waveforms and disease duration, HbA1c, glycemic control, and short-term increases and decreases in blood glucose levels are evaluated. VEP may be useful for predicting postoperative prognosis and evaluating visual function before surgery for diabetic retinopathy. Further controlled studies with larger cohorts are needed to establish a more detailed relationship between diabetes mellitus and VEP.

Automated summary

Visual evoked potentials (VEP) can detect visual pathway dysfunction in diabetes mellitus caused by abnormalities in blood glucose levels. Previous studies have shown that VEP can detect neuropathy before fundus examination and evaluate the correlation between VEP waveforms and disease duration, HbA1c, glycemic control, and short-term blood glucose fluctuations. VEP may be useful for predicting postoperative prognosis and assessing visual function in diabetic retinopathy. Further research with larger cohorts is needed to establish a more detailed relationship between diabetes mellitus and VEP.