Integrated Small Animal PET/CT/RT with Onboard PET/CT Image Guidance for Preclinical Radiation Oncology Research

Article Radiology, Nuclear Medicine & Medical Imaging

Co-clinical FDG-PET radiomic signature in predicting response to neoadjuvant chemotherapy in triple-negative breast cancer

Sudipta Roy et al.

Summary: The study aimed to optimize radiomic features using patient-derived tumor xenografts (PDX) in predicting therapy response in TNBC, and to implement these features in a co-clinical study using machine learning algorithms to predict therapy response.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2022)

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Article Imaging Science & Photographic Technology

A New Preclinical Decision Support System Based on PET Radiomics: A Preliminary Study on the Evaluation of an Innovative 64Cu-Labeled Chelator in Mouse Models

Viviana Benfante et al.

Summary: In this study, Cu-64-labeled chelator biodistribution in mice was evaluated using positron emission tomography (PET) imaging. The results showed significant variations in uptake of the chelator over time, particularly in the bladder and liver regions.

JOURNAL OF IMAGING (2022)

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Article Engineering, Biomedical

Field-programable-gate-array-based distributed coincidence processor for high count-rate online positron emission tomography coincidence data acquisition

Xinyi Cheng et al.

Summary: In this study, a set of distributed coincidence processors (DCP) were investigated as a practical solution to address the problems of centralized coincidence processors (CCP) in online PET data acquisition. DCP demonstrated the ability to reduce data process delay, maximize count-rates of coincidence events, and simplify implementation by replicating the same coincidence processor. The prototype DCP with 42 coincidence processors showed promising performances in handling pulsed signals and gamma ray interactions, making it a potential solution for online PET acquisition with larger detector pairs or ultrahigh-throughput imaging.

PHYSICS IN MEDICINE AND BIOLOGY (2021)

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Article Engineering, Biomedical

A compact and lightweight small animal PET with uniform high-resolution for onboard PET/CT image-guided preclinical radiation oncology research

Xinyi Cheng et al.

Summary: The compact and lightweight PET technology is designed to provide functional/biological/molecular imaging for preclinical radiation therapy research, demonstrating sufficient capability and performance.

PHYSICS IN MEDICINE AND BIOLOGY (2021)

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Review Oncology