Sensing translocating polymers via induced magnetic fields

The requirement to boost the resolution of nanop ore-based biosequencing devices necessitates the integration of novel biosensing techniques with reduced sensitivity to background noise. In this article, we probe the signatures of translocating polymers in magnetic fields induced by ionic currents through membrane nanopores. Within the framework of a previously introduced charge transport theory, we evaluate the magnetic field signals generated by voltage-and pressure-driven DNA translocation events in monovalent salt solutions. Our formalism reveals that in voltage-driven transport, the translocating polymer suppresses the induced magnetic field via the steric blockage of the ion current through the midpore. In the case of pressure-driven transport, the magnetic field reduction by translocation originates from the negative electrokinetic contribution of the anionic DNA surface charges to the streaming current predominantly composed of salt cations. The magnitude of the corresponding field signals is located in the nano-Tesla range covered by the resolution of the magnetoelectric sensors able to detect magnetic fields down to the pico-Tesla range. This suggests that the integration of magnetic field detection techniques into the current biosequencing approaches can complement efficiently the conventional biosensing strategies employing ionic current readouts with high susceptibility to background noise.

Automated summary

In this article, the signatures of translocating polymers in magnetic fields induced by ionic currents were investigated. It was found that the translocating polymer suppresses the induced magnetic field in voltage-driven transport, while the magnetic field reduction in pressure-driven transport is caused by the negative electrokinetic contribution of anionic DNA surface charges. The integration of magnetic field detection techniques into current biosequencing approaches can efficiently complement conventional biosensing strategies with high susceptibility to background noise.