Poly(Piloty's acid): a slow releasing macromolecular HNO donor

We report a polymeric version of Piloty's acid where the release rate of HNO can be tuned by changing the block ratios of PEG-b-poly(Piloty's acid) in a block copolymer system. The poly(Piloty's acid) block was derived from poly(styrene sulfonate), and HNO release from the block copolymers varied by as much as an order of magnitude via increasing the length of the poly(Piloty's acid) block. We anticipate this study will guide the development of HNO-releasing polymers to measure the effects of sustained HNO delivery in biological systems.

Automated summary

We have developed a polymeric version of Piloty's acid that allows for tuning the release rate of HNO by adjusting the block ratios of PEG-b-poly(Piloty's acid) in a block copolymer system. By increasing the length of the poly(Piloty's acid) block, the HNO release from the block copolymers can vary by up to an order of magnitude. This study has potential implications in the development of HNO-releasing polymers for studying the effects of sustained HNO delivery in biological systems.