Effect of stress hyperglycaemia on acute kidney injury in non-diabetic critically ill patients?

BackgroundStress hyperglycaemia (SH) and acute kidney injury (AKI) occur frequently in critically ill patients, and particularly non-diabetics are associated with adverse outcome. Data is scarce on the effect of SH on AKI. We assessed whether SH (i) preceded AKI, (ii) was a risk factor of subsequent AKI, and (iii) how SH and tubular injury interacted in AKI development in critically ill, non-diabetics.MethodsCase-control study of 82 patients each with and without SH matched by propensity score for multiple demographic characteristics. AKI was defined by KDIGO criteria, SH either as blood glucose (BG) > 140 mg/dl (BG(140)), > 200 mg/dl (BG(200)), or stress hyperglycemia rate (SHR) >= 1.47 (SHR1.47) as measured 2 days before AKI. Urinary cystatin C and neutrophil gelatinase-associated lipocalin (NGAL) indicated tubular injury.ResultsIn AKI, SH rates were frequent using all 3 definitions applied, but highest when BG(140) was applied. SH by all 3 definitions was consistently associated with AKI. This was independent of established risk factors of AKI such as sepsis and shock. Increments of BG, urinary NGAL or cystatin C, and its products, were independently associated with the likelihood of subsequent AKI, demonstrating their reciprocal potentiating effects on AKI development.ConclusionsSH is frequent in critically ill, non-diabetics with AKI. SH was identified as an independent risk factor of AKI. Higher BG combined with tubular injury may potentiate their adverse effects on AKI.

Automated summary

The study aimed to investigate the relationship between stress hyperglycemia (SH) and acute kidney injury (AKI) in non-diabetic critically ill patients. It found that SH was a risk factor for subsequent AKI, and the combination of high blood glucose levels and tubular injury increased the likelihood of AKI development. These findings suggest the importance of monitoring and managing blood glucose levels in critically ill patients to prevent AKI.