Journal
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
Volume 72, Issue -, Pages -Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TIM.2023.3265117
Keywords
Sensors; Electrodes; Impedance; COVID-19; Integrated circuits; Antibodies; Impedance measurement; Biosensor; electronic readout system; impedance measurement; SARS-CoV-2
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This article presents a portable impedimetric biosensor for detecting infectious diseases, such as SARS-CoV-2 infections. A bio-ready sensing electrode functionalized with SARS-CoV-2 nucleocapsid antibody was employed to quantitatively convert the concentration of nucleocapsid protein (N-protein) into impedance changes. The proposed impedimetric sensing system can be adopted for the detection of infectious diseases in the future.
This article presents a portable impedimetric biosensor for detecting infectious diseases, such as SARS-CoV-2 infections. A bio-ready sensing electrode functionalized with SARS-CoV-2 nucleocapsid antibody was employed to quantitatively convert the concentration of nucleocapsid protein (N-protein) into impedance changes. In this article, we proposed a readout system with a dynamic input range of 200-O-1-MO magnitude and 0(?)-180(?) phase. The resolution of this device is 1% and 6.5(?) for measuring the magnitude and phase, respectively. Herein, we demonstrate and discuss the proposed system's functionality, sensitivity, and selectivity using the clinical swab samples. As per these results, this readout system is suitable for the detection of N-protein ranging up to 10 000 pg/mL with a resolution of 56 fg/mL. The proposed impedimetric sensing system can be adopted for the detection of infectious diseases in the future. This low-cost (<$80) device using off-the-shelf is a unique candidate for batch production purposes during urgent pandemic situations.
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