Journal
DEVELOPMENTAL COGNITIVE NEUROSCIENCE
Volume 20, Issue -, Pages 35-42Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.dcn.2016.06.002
Keywords
Adolescence; Risk-taking behavior; Resting-state fMRI; Independent component analysis (ICA); Fronto-parietal network (FPN); Limbic network; Intrinsic network connectivity
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Funding
- National Institute of Health [1R01DA039923]
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Recent developmental brain imaging studies have demonstrated that negatively coupled prefrontal limbic circuitry implicates the maturation of brain development in adolescents. Using resting-state functional magnetic resonance imaging (rs-fMRI) and independent component analysis (ICA), the present study examined functional network coupling between prefrontal and limbic systems and links to self-control and substance use onset in adolescents. Results suggest that negative network coupling (anti-correlated temporal dynamics) between the right fronto-parietal and limbic resting state networks is associated with greater self-control and later substance use onset in adolescents. These findings increase our understanding of the developmental importance of prefrontal-limbic circuitry for adolescent substance use at the resting-state network level. (C) 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license.
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