6-Gingerol-derived semisynthetic analogs mitigate oxidative stress, and reverse acrylamide induced neurotoxicity in zebrafish

A semisynthetic strategy has been developed for the synthesis of novel 6-gingerol based analogs using simple and robust chemistries. These newer analogs were able to quench ROS and RNS in vitro, and retrieve the oxidative stress induced by acrylamide in zebrafish larvae. They are also capable of restoring the locomotion behavior in zebrafish.

Automated summary

A semisynthetic strategy was developed to synthesize novel analogs based on 6-gingerol, using simple and robust chemistries. These analogs demonstrated the ability to quench ROS and RNS in vitro, and alleviate oxidative stress induced by acrylamide in zebrafish larvae. They also restored locomotion behavior in zebrafish.