Journal
CURRENT PROBLEMS IN PEDIATRIC AND ADOLESCENT HEALTH CARE
Volume 46, Issue 7, Pages 213-228Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cppeds.2016.04.002
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Osteosarcoma (OS) and the Ewing sarcoma family of tumors (ESFT) are the most common malignant bone tumors in children and adolescents. While significant improvements in survival have been seen in other pediatric malignancies the treatment and prognosis for pediatric bone tumors has remained unchanged for the past 3 decades. This review and update of pediatric malignant bone tumors will provide a general overview of osteosarcoma and the Ewing sarcoma family of tumors, discuss bone tumor genomics, current challenges, and emerging drug targets.
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