Journal
CURRENT OPINION IN VIROLOGY
Volume 16, Issue -, Pages 15-23Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.coviro.2015.10.008
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Funding
- National Institutes of Health [DA038017, AI118179]
- Cincinnati Children's Research Foundation
- Alpha Omega Alpha Honor Medical Society
- Albert J. Ryan Foundation
- CancerFree KIDS Pediatric Cancer Research Alliance
- Ellison Medical Foundation
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Natural killer (NK) cells are important in immune defense against virus infections. This is predominantly considered a function of rapid, innate NK-cell killing of virus-infected cells. However, NK cells also prime other immune cells through the release of interferon gamma (IFN-gamma) and other cytokines. Additionally, NK cells share features with long-lived adaptive immune cells and can impact disease pathogenesis through the inhibition of adaptive immune responses by virus-specific T and B cells. The relative contributions of these diverse and conflicting functions of NK cells in humans are poorly defined and likely context-dependent, thereby complicating the development of therapeutic interventions. Here we focus on the contributions of NK cells to disease in diverse virus infections germane to human health.
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