4.3 Review

Respiratory therapies for Amyotrophic Lateral Sclerosis: A state of the art review

Related references

Note: Only part of the references are listed.
Article Otorhinolaryngology

Predictors of Peak Expiratory Cough Flow in Individuals with Amyotrophic Lateral Sclerosis

Lauren Tabor Gray et al.

Summary: This study aimed to identify predictors of peak expiratory cough flow rate in individuals with ALS. The research highlighted the importance of both inspiratory and expiratory strength in generating high-velocity expiratory airflow to clear the airway. Therapeutic training programs targeting both inspiratory and expiratory strength may improve airway clearance capacity in this patient population.

DYSPHAGIA (2023)

Review Neurosciences

Acute intermittent hypoxia and respiratory muscle recruitment in people with amyotrophic lateral sclerosis: A preliminary study

Elaheh Sajjadi et al.

Summary: Respiratory failure is the primary cause of death in ALS patients, with a lack of effective treatments. Studies have shown that acute intermittent hypoxia can enhance respiratory muscle activity in both ALS patients and controls, improving tidal volume and minute ventilation, but leading to a decrease in SNIP similarity index in the control group.

EXPERIMENTAL NEUROLOGY (2022)

Article Clinical Neurology

Survival analyses from the CENTAUR trial in amyotrophic lateral sclerosis: Evaluating the impact of treatment crossover on outcomes

Sabrina Paganoni et al.

Summary: This study utilized the RPSFTM survival analysis method to analyze data from the CENTAUR trial in ALS, and the results showed a significant survival benefit of PB and TURSO compared to placebo. The findings of this study may contribute to the clinical application of observed survival outcomes in future ALS crossover trials.

MUSCLE & NERVE (2022)

Article Respiratory System

Routine lung volume recruitment in boys with Duchenne muscular dystrophy: a randomised clinical trial

Sherri L. Katz et al.

Summary: This randomized controlled trial aimed to determine whether twice-daily lung volume recruitment (LVR) therapy attenuates the decline in forced vital capacity (FVC) at 2 years in boys with Duchenne muscular dystrophy (DMD). The results showed that there was no difference in decline in FVC with the use of twice-daily LVR for boys with relatively normal lung function.

THORAX (2022)

Article Medicine, General & Internal

Home-Based Adaptation to Night-Time Non-Invasive Ventilation in Patients with Amyotrophic Lateral Sclerosis: A Randomized Controlled Trial

Eleonora Volpato et al.

Summary: In ALS patients, home-based adaptation to NIV is as effective as outpatient adaptation in terms of PaCO2, acceptance, and adherence, highlighting the need for further studies on the role of the environment in NIV adherence.

JOURNAL OF CLINICAL MEDICINE (2022)

Article Clinical Neurology

Sodium Phenylbutyrate and Ursodoxicoltaurine: First Approval

Young-A Heo

Summary: Amylyx Pharmaceuticals is developing an oral, fixed-dose coformulation for the treatment of neurodegenerative diseases. The coformulation has received conditional approval in Canada for the treatment of amyotrophic lateral sclerosis (ALS) in adults. The approval was based on the positive results from the clinical trial of sodium phenylbutyrate/ursodoxicoltaurine.

CNS DRUGS (2022)

Article Critical Care Medicine

Caffeine Enhances Intermittent Hypoxia-Induced Gains in Walking Function for People with Chronic Spinal Cord Injury

Randy D. Trumbower et al.

Summary: This study aimed to test whether a non-selective A2aR antagonist, caffeine, enhances the effects of acute intermittent hypoxia (AIH) on walking function in individuals with chronic incomplete spinal cord injury (iSCI). The results showed that participants in the caffeine+AIH group walked faster and farther, and the improvement in speed lasted longer.

JOURNAL OF NEUROTRAUMA (2022)

Article Medicine, General & Internal

POWERbreathe(R) Inspiratory Muscle Training in Amyotrophic Lateral Sclerosis

Davinia Vicente-Campos et al.

Summary: Inspiratory muscle training with POWERbreathe(R) may improve inspiratory strength and heart rate in patients with Amyotrophic Lateral Sclerosis (ALS). This pilot study found significant differences in maximum inspiratory pressure, heart rate, and heart rate variability between the experimental group who received inspiratory muscle training and the control group who received usual care. The results suggest that inspiratory muscle training could be beneficial for ALS patients and further research is warranted.

JOURNAL OF CLINICAL MEDICINE (2022)

Article Critical Care Medicine

Waveforms Analysis in PatientsWith Amyotrophic Lateral Sclerosis for Enhanced Efficacy of Mechanically Assisted Coughing

Jesus Sancho et al.

Summary: This study evaluated the use of graphs generated by MI-E in ALS to detect airway obstruction and set parameters for effective mechanically assisted coughing. The results showed that obstruction during insufflation was related to bulbar upper motor neuron dysfunction, while collapse during exsufflation was related to bulbar lower motor neuron dysfunction.

RESPIRATORY CARE (2022)

Article Audiology & Speech-Language Pathology

Pilot Study of Respiratory-Swallow Coordination in Amyotrophic Lateral Sclerosis

Kendrea L. (Focht) Garand et al.

Summary: The purpose of this pilot study was to examine if respiratory-swallow coordination is impaired in individuals with ALS compared to healthy controls, and to explore the relationship between respiratory function and self-reported swallowing outcomes. The results showed altered respiratory-swallow phase patterning in ALS, and a significant association between group (ALS), swallow tasks, and peak cough flow (PCF) with respiratory-swallow phase pattern. Future work should employ instrumental assessment to further investigate the relationship between perturbed respiratory-swallow coordination and swallowing function.

JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH (2022)

Article Respiratory System

Multiple breath washout lung function reveals ventilation inhomogeneity unresponsive to mechanical assisted cough in patients with neuromuscular disease

Mathis Steindor et al.

Summary: Respiratory involvement in neuromuscular diseases goes beyond weakness of respiratory muscles. Multiple breath washout lung function with nitrogen and sulfur hexafluoride can detect ventilation inhomogeneity in neuromuscular disease patients with respiratory impairment. Cough assist devices with low to moderate pressure levels do not immediately improve lung clearance index.

BMC PULMONARY MEDICINE (2022)

Article Respiratory System

Rapidly and slowly progressive neuromuscular disease: differences in pulmonary function, respiratory tract infections and response to lung volume recruitment therapy (LVR)

Nicole L. Sheers et al.

Summary: This study evaluated respiratory function and the immediate impact of lung volume recruitment (LVR) therapy in patients with neuromuscular disease (NMD). The results showed that lung volumes and respiratory system compliance were lower in NMD patients, but the reduction in respiratory muscle strength was similar. LVR therapy improved respiratory system compliance.

BMJ OPEN RESPIRATORY RESEARCH (2022)

Review Clinical Neurology

Polysomnographic Predictors of Sleep, Motor, and Cognitive Dysfunction Progression in Parkinson's Disease

Femke Dijkstra et al.

Summary: This systematic review explores the significance of polysomnographic variables in predicting sleep dysfunction, motor progression, and cognitive deterioration in Parkinson's disease. Findings suggest that certain sleep disturbances, such as REM sleep behavioral events and EEG changes, may serve as predictors for the development of specific symptoms and disease progression.

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS (2022)

Article Clinical Neurology

Fiberoptic laryngoscopic neurological examination of amyotrophic lateral sclerosis patients with bulbar symptoms

Hiroshi Yaguchi et al.

Summary: This study aimed to characterize the pharyngeal findings in amyotrophic lateral sclerosis (ALS) using a fiberoptic laryngoscope and compare them with the findings of general neurological examination. The specific findings of laryngoscopy in ALS patients, such as speech-swallow dissociation (SSD) in velopharyngeal closure and laterality in pharyngeal constriction, could not be evaluated by general neurological examination via the mouth.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2022)

Review Medicine, General & Internal

Amyotrophic lateral sclerosis

Eva L. Feldman et al.

Summary: Amyotrophic lateral sclerosis, a fatal CNS neurodegenerative disease, lacks optimal management strategies. Improved understanding of clinical presentation, pathophysiology, and diagnostic criteria has not yet translated into direct patient benefit. However, the concept of amyotrophic lateral sclerosis as a complex syndrome is already influencing clinical practice.

LANCET (2022)

Article Physiology

Exploring inspiratory occlusion metrics to assess respiratory drive in patients under acute intermittent hypoxia

Victoria R. Rodrigues et al.

Summary: This study investigates disease progression in ALS patients by assessing respiratory strength and compensatory strategies. The results indicate a positive impact of Acute Intermittent Hypoxia (AIH) on respiratory compensation in ALS patients.

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY (2022)

Article Medicine, General & Internal

Intravenous edaravone treatment in ALS and survival: An exploratory, retrospective, administrative claims analysis

Benjamin Rix Brooks et al.

Summary: This study evaluated the overall survival of US patients with amyotrophic lateral sclerosis (ALS) treated with intravenous (IV) edaravone compared to those not treated with IV edaravone in a real-world setting. The findings showed that IV edaravone treatment was associated with prolonged overall survival in a large cohort of predominantly riluzole-treated ALS patients in the US.

ECLINICALMEDICINE (2022)

Article Medicine, General & Internal

Setting Mechanical Insufflation-Exsufflation (MIE) Pressures for Amyotrophic Lateral Sclerosis (ALS) Patients to Improve Atelectasis and Reduce Risk of Pneumothorax: A Case Report

Keiichi Funo et al.

Summary: This study reports a case of using MI-E to treat an ALS patient. Due to the patient's short height, low BMI, and restricted lung capacity, the MI-E pressure was adjusted to prevent pneumothorax. The results showed that setting the pressure level lower than the manufacturer's recommendation was still effective in improving atelectasis without causing pneumothorax. This study suggests that using MI-E at lower pressures, along with treatment response observation, can reduce the risk of lung injury.

CUREUS JOURNAL OF MEDICAL SCIENCE (2022)

Article Respiratory System

Short-term effect of air stacking and mechanical insufflation-exsufflation on lung function in patients with neuromuscular diseases

Esther S. Veldhoen et al.

Summary: The short-term effects of air stacking and mechanical insufflation-exsufflation on lung function in patients with neuromuscular diseases were studied. Both treatments showed immediate improvements in forced vital capacity and forced expiratory volume, with the effects lasting up to 1 hour after treatment. The effects were more pronounced in patients diagnosed with spinal muscular atrophy.

CHRONIC RESPIRATORY DISEASE (2022)

Article Otorhinolaryngology

Reflexive Airway Sensorimotor Responses in Individuals with Amyotrophic Lateral Sclerosis

Lauren Tabor-Gray et al.

Summary: Individuals with ALS demonstrated increased sensitivity to an upper airway irritant, but displayed slower and weaker expiratory cough motor output compared to healthy controls. In ALS silent aspirators, blunted sensorimotor responses were observed, suggesting that sensory degradation may occur at the final or most severe stage of bulbar disease progression.

DYSPHAGIA (2021)

Article Clinical Neurology

Polysomnographic predictors of sleep, motor and cognitive dysfunction progression in Parkinson's disease: a longitudinal study

Paulo Bugalho et al.

Summary: This study suggests that PSG data could be valuable for predicting the progression of cognitive and sleep dysfunction in PD patients. Lower N3 percentage at baseline was associated with cognitive decline, while baseline PLMS index and presence of RBD were linked to worsening daytime sleep dysfunction. Severity of RBD was a predictor for nighttime sleep symptom progression.

SLEEP MEDICINE (2021)

Article Respiratory System

Objective measurement of lung volume recruitment therapy: laboratory and clinical validation

Phoebe E. Naughton et al.

Summary: A new lung volume recruitment counter was tested in both laboratory and community settings, with the minimum activation pressure under zero leak conditions being 1.9cmH2O. Interface leak led to underestimation of repetition counts, and faster sampling frequency improved data fidelity. Counter data agreed with diary self-report during community trials, but discrepancies tended to favor diary-reported sessions over counter-recorded sessions.

BMJ OPEN RESPIRATORY RESEARCH (2021)

Article Clinical Neurology

Heterogeneity of predictors of nocturnal hypoventilation in amyotrophic lateral sclerosis

Grazia Crescimanno et al.

Summary: In ALS patients, respiratory and muscle function parameters are differently related to NH based on spinal and bulbar presentation. SNIP and BE may help identify NH in spinal patients, while no tests reliably predict NH in bulbar patients.

AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION (2021)

Article Orthopedics

Inspiratory muscle training in neuromuscular patients: Assessing the benefits of a novel protocol

Bruno Cabrita et al.

Summary: The study demonstrated that incorporating inspiratory muscle training into the treatment of neuromuscular patients can significantly improve their respiratory function and coughing capacity, with high compliance to the training protocol. Further larger studies are needed to validate the long-term clinical benefits.

JOURNAL OF BACK AND MUSCULOSKELETAL REHABILITATION (2021)

Article Neurosciences

Daily acute intermittent hypoxia combined with walking practice enhances walking performance but not intralimb motor coordination in persons with chronic incomplete spinal cord injury

Andrew Q. Tan et al.

Summary: Persons with incomplete spinal cord injuries often struggle to regain independent walking due to deficits in walking mechanics. Recent studies have shown that daily bouts of breathing low oxygen prior to locomotor training can lead to persistent improvement in overground walking speed and endurance. However, the effect on intralimb coordination remains untested.

EXPERIMENTAL NEUROLOGY (2021)

Article Clinical Neurology

Respiratory parameters on diagnostic sleep studies predict survival in patients with amyotrophic lateral sclerosis

Markus Engel et al.

Summary: In ALS patients, EMBE > 2 mmol/l predicts nocturnal hypercapnia and shorter survival. The negative effects of sleep-disordered breathing on survival are eliminated by sustained NIV. EMBE is the only predictor for survival from symptom onset in baseline sleep studies.

JOURNAL OF NEUROLOGY (2021)

Article Neurosciences

Accelerated Early Progression of Amyotrophic Lateral Sclerosis over the COVID-19 Pandemic

Fabiola De Marchi et al.

Summary: The COVID-19 lockdown significantly increased the rate of ALS progression, leading to worsening clinical manifestations and higher mortality rates. Factors contributing to this may include lack of multidisciplinary follow-up, social isolation, and suspension of rehabilitation therapy.

BRAIN SCIENCES (2021)

Article Integrative & Complementary Medicine

Effect of inspiratory muscle training on dyspnea-related kinesiophobia in chronic obstructive pulmonary disease: A randomized controlled trial

Seda Saka et al.

Summary: This study identified the presence of dyspnea-related kinesiophobia in COPD patients and showed that IMT reduced this fear, improved respiratory function, and exercise capacity. The results also supported the other known benefits of IMT, including reduced dyspnea and symptom perception, decreased anxiety and depression, and improved quality of life.

COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE (2021)

Review Neurosciences

Efficacy and time course of acute intermittent hypoxia effects in the upper extremities of people with cervical spinal cord injury

Milap S. Sandhu et al.

Summary: Acute intermittent hypoxia (AIH) can enhance upper-extremity function in individuals with incomplete SCI. A single AIH session improves bilateral grip and pinch strength, peaking around 3 hours post-intervention, significantly higher than sham AIH.

EXPERIMENTAL NEUROLOGY (2021)

Review Neurosciences

Single-session effects of acute intermittent hypoxia on breathing function after human spinal cord injury

Tommy Sutor et al.

Summary: The study found that a single session of acute intermittent hypoxia (AIH) can increase maximal inspiratory pressure generation in adults with chronic spinal cord injury (SCI), but does not affect other breathing functions. Further investigation into the potential therapeutic effects is warranted.

EXPERIMENTAL NEUROLOGY (2021)

Article Clinical Neurology

Lung volume recruitment improves volitional airway clearance in amyotrophic lateral sclerosis

Stuart Cleary et al.

Summary: This study evaluated the effects of lung volume recruitment treatment (LVR) on volitional airway clearance and protection behaviors in people with ALS. LVR treatment significantly increased maximum expiratory rates during all tested behaviors, with effects lasting up to 30 minutes post-treatment. The findings have implications for patient care, offering control over ALS symptoms and improved respiratory care in low-resource settings.

MUSCLE & NERVE (2021)

Article Respiratory System

Noninvasive Ventilation Use Is Associated with Better Survival in Amyotrophic Lateral Sclerosis

Jason Ackrivo et al.

Summary: This study showed that the use of NIV was associated with better survival rates in ALS patients, especially in those with limb-onset ALS. Increasing daily NIV usage was linked to longer survival.

ANNALS OF THE AMERICAN THORACIC SOCIETY (2021)

Article Respiratory System

Long-Term Mechanical Ventilation: Recommendations of the Swiss Society of Pulmonology

Jean-Paul Janssens et al.

Summary: Long-term mechanical ventilation is a well-established treatment for chronic hypercapnic respiratory failure, with broadening applications and most frequent indications including chronic obstructive pulmonary disease, obesity hypoventilation syndrome, neuromuscular and chest wall diseases.

RESPIRATION (2021)

Review Clinical Neurology

Sleep and Sleep Disruption in Amyotrophic Lateral Sclerosis

Matthias Boentert

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS (2020)

Article Pediatrics

Lung clearance index: A new measure of late lung complications of cancer therapy in children

Giuseppe F. Parisi et al.

PEDIATRIC PULMONOLOGY (2020)

Review Clinical Neurology

Clinical Measures of Bulbar Dysfunction in ALS

Yana Yunusova et al.

FRONTIERS IN NEUROLOGY (2019)

Article Critical Care Medicine

Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis

Adam V. Benjafield et al.

LANCET RESPIRATORY MEDICINE (2019)

Article Respiratory System

Human diaphragm atrophy in amyotrophic lateral sclerosis is not predicted by routine respiratory measures

Raquel Guimaraes-Costa et al.

EUROPEAN RESPIRATORY JOURNAL (2019)

Article Clinical Neurology

Effects of Sleep-Related Disorders on the Prognosis of Amyotrophic Lateral Sclerosis

Aylin Reyhani et al.

NEURODEGENERATIVE DISEASES (2019)

Review Clinical Neurology

Non-invasive ventilation in amyotrophic lateral sclerosis

Johannes Dorst et al.

THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS (2019)

Article Clinical Neurology

Prevalence of sleep apnoea and capnographic detection of nocturnal hypoventilation in amyotrophic lateral sclerosis

Matthias Boentert et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2018)

Review Respiratory System

Effects of inspiratory muscle training in COPD patients: A systematic review and meta-analysis

Marc Beaumont et al.

CLINICAL RESPIRATORY JOURNAL (2018)

Article Physiology

Inspiratory muscle training reduces diaphragm activation and dyspnea during exercise in COPD

Daniel Langer et al.

JOURNAL OF APPLIED PHYSIOLOGY (2018)

Review Cardiac & Cardiovascular Systems

Airway clearance techniques in neuromuscular disorders: A state of the art review

Michelle Chatwin et al.

RESPIRATORY MEDICINE (2018)

Article Neurosciences

Mechanisms of Enhanced Phrenic Long-Term Facilitation in SOD1G93A Rats

Nicole L. Nichols et al.

JOURNAL OF NEUROSCIENCE (2017)

Article Clinical Neurology

The evaluation of bulbar dysfunction in amyotrophic lateral sclerosis: survey of clinical practice patterns in the United States

Emily K. Plowman et al.

AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION (2017)

Article Clinical Neurology

Identifying who will benefit from non-invasive ventilation in amyotrophic lateral sclerosis/motor neurone disease in a clinical cohort

David J. Berlowitz et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2016)

Article Clinical Neurology

Trial of early noninvasive ventilation for ALS A pilot placebo-controlled study

Teresa L. Jacobs et al.

NEUROLOGY (2016)

Article Medicine, General & Internal

A Comparison of Cough Assistance Techniques in Patients with Respiratory Muscle Weakness

Sun Mi Kim et al.

YONSEI MEDICAL JOURNAL (2016)

Review Clinical Neurology

Pulmonary Physical Therapy Techniques to Enhance Survival in Amyotrophic Lateral Sclerosis: A Systematic Review

Chelsea E. Macpherson et al.

JOURNAL OF NEUROLOGIC PHYSICAL THERAPY (2016)

Article Respiratory System

Long-Term Effects of Lung Volume Recruitment on Maximal Inspiratory Capacity and Vital Capacity in Duchenne Muscular Dystrophy

Sherri L. Katz et al.

ANNALS OF THE AMERICAN THORACIC SOCIETY (2016)

Article Physiology

Intermittent hypoxia: a low-risk research tool with therapeutic value in humans

Jason H. Mateika et al.

JOURNAL OF APPLIED PHYSIOLOGY (2015)

Review Physiology

Intermittent hypoxia and neurorehabilitation

Elisa J. Gonzalez-Rothi et al.

JOURNAL OF APPLIED PHYSIOLOGY (2015)

Article Clinical Neurology

Noninvasive Ventilation Improves Sleep in Amyotrophic Lateral Sclerosis: A Prospective Polysomnographic Study

Bart Vrijsen et al.

JOURNAL OF CLINICAL SLEEP MEDICINE (2015)

Article Critical Care Medicine

Bench Comparative Assessment of Mechanically Assisted Cough Devices

Pamela Frigerio et al.

RESPIRATORY CARE (2015)

Article Clinical Neurology

A preliminary randomized trial of the mechanical insufflator-exsufflator versus breath-stacking technique in patients with amyotrophic lateral sclerosis

Muhammad K. Rafiq et al.

AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION (2015)

Review Physiology

Therapeutic potential of intermittent hypoxia: a matter of dose

Angela Navarrete-Opazo et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2014)

Article Critical Care Medicine

Long-Term Facilitation of Ventilation in Humans with Chronic Spinal Cord Injury

Nicole J. Tester et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2014)

Article Respiratory System

Air stacking: effects on pulmonary function in patients with spinal muscular atrophy and in patients with congenital muscular dystrophy

Tanyse Bahia Carvalho Marques et al.

JORNAL BRASILEIRO DE PNEUMOLOGIA (2014)

Review Clinical Neurology

Breathing new life into treatment advances for respiratory failure in amyotrophic lateral sclerosis patients

Susana Pinto et al.

NEURODEGENERATIVE DISEASE MANAGEMENT (2014)

Article Clinical Neurology

Dysphagia in amyotrophic lateral sclerosis: prevalence and clinical findings

G. Ruoppolo et al.

ACTA NEUROLOGICA SCANDINAVICA (2013)

Article Dentistry, Oral Surgery & Medicine

Oropharyngeal dysphagia in amyotrophic lateral sclerosis alters quality of life

G. Paris et al.

JOURNAL OF ORAL REHABILITATION (2013)

Article Clinical Neurology

The effects of lung volume recruitment on coughing and pulmonary function in patients with ALS

Stuart Cleary et al.

AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION (2013)

Article Psychology, Clinical

Determinants of accepting non-invasive ventilation treatment in motor neurone disease: a quantitative analysis at point of need

Rosanna Cousins et al.

HEALTH PSYCHOLOGY AND BEHAVIORAL MEDICINE (2013)

Article Rehabilitation

Lung Volume Recruitment Slows Pulmonary Function Decline in Duchenne Muscular Dystrophy

Douglas A. McKim et al.

ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION (2012)

Article Clinical Neurology

Exposure to Acute Intermittent Hypoxia Augments Somatic Motor Function in Humans With Incomplete Spinal Cord Injury

Randy D. Trumbower et al.

NEUROREHABILITATION AND NEURAL REPAIR (2012)

Article Multidisciplinary Sciences

Spinal plasticity following intermittent hypoxia: implications for spinal injury

Erica A. Dale-Nagle et al.

NEURONS AND NETWORKS IN THE SPINAL CORD (2010)

Article Physiology

Evaluation of respiratory muscle activation in individuals with chronic spinal cord injury

Alexander Ovechkin et al.

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY (2010)

Article Clinical Neurology

INSPIRATIonAL - INSPIRAtory muscle training in amyotrophic lateral sclerosis

Benjamin C. Cheah et al.

AMYOTROPHIC LATERAL SCLEROSIS (2009)

Review Respiratory System

Chronic respiratory care for neuromuscular diseases in adults

N. Ambrosino et al.

EUROPEAN RESPIRATORY JOURNAL (2009)

Review Genetics & Heredity

Amyotrophic lateral sclerosis

Lokesh C. Wijesekera et al.

ORPHANET JOURNAL OF RARE DISEASES (2009)

Review Clinical Neurology

Diagnosis and treatment of bulbar symptoms in amyotrophic lateral sclerosis

Peter Kuehnlein et al.

NATURE CLINICAL PRACTICE NEUROLOGY (2008)

Article Clinical Neurology

Physical decline and quality of life in amyotrophic lateral sclerosis

O Hardiman et al.

AMYOTROPHIC LATERAL SCLEROSIS (2004)

Article Respiratory System

Cough augmentation with mechanical insufflation/exsufflation in patients with neuromuscular weakness

M Chatwin et al.

EUROPEAN RESPIRATORY JOURNAL (2003)