Journal
CURRENT OPINION IN VIROLOGY
Volume 21, Issue -, Pages 75-80Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.coviro.2016.08.003
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Funding
- Public Health Service grants from the National Institutes of Health [R01 HL-097088, R21 EB-015684]
- Children's Miracle Network
- Kitzman Foundation
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In this review, a brief account of the historical perspective of the discovery of the first cellular receptor and co-receptor of the prototype adeno-associated virus serotype 2 (AAV2) will be presented. The Subsequent discovery of a number of AAV serotypes, and attempts to identify the cellular receptors and co-receptors for these serotype vectors has had significant implications in their use in human gene therapy. As additional AAV serotypes are discovered and isolated, a detailed understanding of their tropism is certainly likely to play a key role in all future studies, both basic science as well as clinical.
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