Journal
CURRENT OPINION IN VIROLOGY
Volume 21, Issue -, Pages 1-8Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.coviro.2016.06.001
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This chapter reviews the performance of viral vectors based on adenoviruses or adeno-associated virus as vaccine carriers for infectious diseases. Replication-defective adenovirus vectors based on multiple human or non-human serotypes have consistently induced potent transgene product-specific B and T cell responses and are increasingly being explored in human clinical trials. The immunogenicity of most vectors based on adeno-associated virus vectors has been poor with the exception of a recently described hybrid vector from rhesus macaques that due to its ability to induce potent responses in mice warrant further investigation.
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