Journal
CURRENT OPINION IN VIROLOGY
Volume 19, Issue -, Pages 92-98Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.coviro.2016.07.012
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Funding
- National Institutes of Health [NS040237]
- TNPRC Base Grant TNPRC PSI [ODO1114]
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Non-human primate models of AIDS and neuroAlDS are the premiere model of HIV infection of the CNS and neuropathogenesis. This review discusses current SIV infection models of neuroAlDS emphasizing findings in the last two years. Consistent in these findings is the interplay between host factors that regulate immune responses to virus and viral replication. Several rapid models of AIDS with consistent CNS pathogenesis exist, each of which modulates by antibody treatment or viruses that cause rapid immune suppression and replicate well in macrophages. Consistent in all of these models are data underscoring the importance of monocyte and macrophage activation, infection and accumulation in the CNS.
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