Journal
CURRENT OPINION IN VIROLOGY
Volume 19, Issue -, Pages 7-10Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.coviro.2016.05.007
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Funding
- National Institutes of Health [AI080703, DK102883]
- American Cancer Society [118676-RSG-10-059-01-MPC]
- NIH [DK102883]
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Over the last decade, we have begun to appreciate how flaviviruses manipulate cellular metabolism to establish an optimal environment for their replication. These metabolic changes include the stimulation of glycolysis, in addition to lipid anabolic and catabolic pathways. These processes are thought to promote an energetically favorable state, in addition to modifying membrane lipid composition for viral replication and virion envelopment. Importantly, many of these processes can be pharmacologically inhibited as successful antiviral strategies, at least in cell culture. In this review, we discuss the mechanisms by which flaviviruses alter cellular metabolism, remaining questions, and opportunities for therapeutic development.
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