Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 11, Issue 24, Pages 5390-5399Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d3tb00156c
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In this article, we propose a new opportunity to target intracellular compartments by delivering antagonists via nanoparticles to G-protein coupled receptors. We specifically discuss the application of this approach in antagonizing endosomal receptors involved in pain for developing long-lasting analgesics, and also highlight the potential broader applications. We also discuss the materials used and provide design requirements for future successful applications.
In this perspective, we outline a new opportunity for exploiting nanoparticle delivery of antagonists to target G-protein coupled receptors localized in intracellular compartments. We discuss the specific example of antagonizing endosomal receptors involved in pain to develop long-lasting analgesics but also outline the broader application potential of this delivery approach. We discuss the materials used to target endosomal receptors and indicate the design requirements for future successful applications.
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