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From gatekeepers to providers: regulation of immune functions by cancer-associated fibroblasts

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CD10+ GPR77+ Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness

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CELL (2018)

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Cancer-Associated Fibroblasts Affect Intratumoral CD8+ and FoxP3+ T Cells Via IL6 in the Tumor Microenvironment

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CLINICAL CANCER RESEARCH (2018)

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Cancer-Stimulated CAFs Enhance Monocyte Differentiation and Protumoral TAM Activation via IL6 and GM-CSF Secretion

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CLINICAL CANCER RESEARCH (2018)

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Fibroblast activation proteins-α suppress tumor immunity by regulating T cells and tumor-associated macrophages

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EXPERIMENTAL AND MOLECULAR PATHOLOGY (2018)

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CD4 Helper and CD8 Cytotoxic T Cell Differentiation

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ANNUAL REVIEW OF IMMUNOLOGY, VOL 36 (2018)

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Phenotype molding of stromal cells in the lung tumor microenvironment

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NATURE MEDICINE (2018)

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Dual Transforming Growth Factor-β and Programmed Death-1 Blockade: A Strategy for Immune-Excluded Tumors?

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TRENDS IN IMMUNOLOGY (2018)

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Cancer-associated fibroblasts induce PDL1+neutrophils through the IL6-STAT3 pathway that foster immune suppression in hepatocellular carcinoma

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CELL DEATH & DISEASE (2018)

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Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer

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Cancer-associated fibroblasts induce antigen-specific deletion of CD8+ T Cells to protect tumour cells

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NATURE COMMUNICATIONS (2018)

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FRONTIERS IN IMMUNOLOGY (2018)

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The prognostic significance of carcinoma-associated fibroblasts and tumor-associated macrophages in nasopharyngeal carcinoma

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FAP Delineates Heterogeneous and Functionally Divergent Stromal Cells in Immune-Excluded Breast Tumors

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CANCER IMMUNOLOGY RESEARCH (2018)

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Bone marrow-derived fibroblasts are a functionally distinct stromal cell population in breast cancer

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Link between tumor-promoting fibrous microenvironment and an immunosuppressive microenvironment in stage I lung adenocarcinoma

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LUNG CANCER (2018)

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Myofibroblast proliferation and heterogeneity are supported by macrophages during skin repair

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SCIENCE (2018)

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TGF-β-associated extracellular matrix genes link cancer-associated fibroblasts to immune evasion and immunotherapy failure

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NATURE COMMUNICATIONS (2018)

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Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing

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NATURE COMMUNICATIONS (2018)

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Cancer-Associated Fibroblasts Correlate with Tumor-Associated Macrophages Infiltration and Lymphatic Metastasis in Triple Negative Breast Cancer Patients

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JOURNAL OF CANCER (2018)

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Alteration of the Tumor Stroma Using a Consensus DNA Vaccine Targeting Fibroblast Activation Protein (FAP) Synergizes with Antitumor Vaccine Therapy in Mice

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CLINICAL CANCER RESEARCH (2018)

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Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

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JOURNAL OF EXPERIMENTAL MEDICINE (2017)

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Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors

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NATURE GENETICS (2017)

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KLF4-dependent perivascular cell plasticity mediates pre-metastatic niche formation and metastasis

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NATURE MEDICINE (2017)

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Fibroblasts drive an immunosuppressive and growth-promoting microenvironment in breast cancer via secretion of Chitinase 3-like 1

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ONCOGENE (2017)

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Tumor hypoxia modulates podoplanin/CCL21 interactions in CCR7+ NK cell recruitment and CCR7+ tumor cell mobilization

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Myeloid-Derived Suppressor Cells

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CANCER IMMUNOLOGY RESEARCH (2017)

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FRONTIERS IN IMMUNOLOGY (2017)

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Pancreatic cancer cell/fibroblast co-culture induces M2 like macrophages that influence therapeutic response in a 3D model

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PLOS ONE (2017)

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Cancer-Associated Fibroblasts Neutralize the Anti-tumor Effect of CSF1 Receptor Blockade by Inducing PMN-MDSC Infiltration of Tumors

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Cancer-Associated Fibroblasts Share Characteristics and Protumorigenic Activity with Mesenchymal Stromal Cells

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FAP Promotes Immunosuppression by Cancer-Associated Fibroblasts in the Tumor Microenvironment via STAT3-CCL2 Signaling

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CANCER RESEARCH (2016)

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GENES & DEVELOPMENT (2016)

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Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy

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NATURE REVIEWS CANCER (2016)

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CANCER CELL (2015)

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Cancer-associated fibroblasts induce epithelial-mesenchymal transition of breast cancer cells through paracrine TGF-β signalling

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BRITISH JOURNAL OF CANCER (2014)

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Stromally Derived Lysyl Oxidase Promotes Metastasis of Transforming Growth Factor-β-Deficient Mouse Mammary Carcinomas

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Distinct epigenetic changes in the stromal cells of breast cancers

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Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion

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