Journal
MATTER
Volume 6, Issue 3, Pages 1015-1036Publisher
CELL PRESS
DOI: 10.1016/j.matt.2023.01.011
Keywords
complex material system; robust model selection; granular matrices; complex
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This study combines experimentation and computation to design granular matrices with controlled properties, allowing for potential applications in cell encapsulation, bioprinting, and tissue engineering.
Granular hydrogel matrices have emerged as promising candidates for cell encapsulation, bioprinting, and tissue engineering. How-ever, it remains challenging to design and optimize these materials given their broad compositional and processing parameter space. Here, we combine experimentation and computation to create granular matrices composed of alginate-based bioblocks with controlled structure, rheological properties, and injectability pro-files. A custom machine learning pipeline is applied after each phase of experimentation to automatically map the multidimensional input-output patterns into condensed data-driven models. These models are used to assess generalizable predictability and define high-level design rules to guide subsequent phases of development and characterization. Our integrated, modular approach opens new avenues to understanding and controlling the behavior of complex soft materials.
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