Journal
2023 IEEE 36TH INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS, MEMS
Volume -, Issue -, Pages 437-439Publisher
IEEE
DOI: 10.1109/MEMS49605.2023.10052467
Keywords
SARS-CoV-2; point-of-care; COVID-19; LAMP; limit of detection; open-source hardware; total internal reflection; TIR
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Sensitive and rapid on-site detection of SARS-CoV-2 using the PATHPOD device, which employs real-time reverse-transcription loop-mediated isothermal amplification (RT-rLAMP) reaction on a polymer cartridge, has been achieved. The PATHPOD PoC system, consisting of a standalone device and a cartridge, can identify 10 distinct samples and 2 controls in less than 50 minutes. This work presents the fabrication and clinical validation of the PATHPOD PoC system for the first time.
In the ongoing COVID-19 pandemic, sensitive and rapid on-site detection of the SARS-CoV-2 coronavirus has been one of crucial objectives. A point-of-care (PoC) device called PATHPOD for quick, on-site detection of SARS-CoV-2 employing a real-time reverse-transcription loop-mediated isothermal amplification (RT-rLAMP) reaction on a polymer cartridge. The PATHPOD consists of a standalone device (weighing under 1.2 kg) and a cartridge, and can identify 10 distinct samples and 2 controls in less than 50 minutes. The PATHPOD PoC system is fabricated and clinically validated for the first time in this work
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