Journal
JOURNAL OF NUTRITION HEALTH & AGING
Volume 27, Issue 5, Pages 391-397Publisher
SPRINGER FRANCE
DOI: 10.1007/s12603-023-1921-1
Keywords
All-cause mortality; cardiovascular mortality; probiotic; prebiotic; synbiotic
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This study found that nonfood pro-, pre-, and synbiotics have a protective effect against all-cause and cardiovascular mortality in Americans aged 65 years or older. Nonfood pro-, pre-, and synbiotics can be a novel, inexpensive, low-risk treatment addition for older individuals to prevent all-cause and cardiovascular mortality.
ObjectivesPro-, pre-, and synbiotic supplements improve cardiovascular risk factors. However, the association between nonfood pro-, pre-, and synbiotics (NPPS) and long-term all-cause and cardiovascular mortality has not been studied. Thus, our objective was to determine the impact of nonfood pro-, pre-, and synbiotics on all-cause and cardiovascular mortality.Design, Setting, and ParticipantsThis was a retrospective, cohort study of 4837 nationally representative American participants aged 65 years or older with a median follow-up duration of 77 months.MeasurementsAll-cause and cardiovascular mortality were measured.ResultsA total of 1556 participants died during the median 77-month follow-up, and 517 died from cardiovascular disease. Compared with participants without NPPS use, participants who used NPPS experienced a reduced risk of all-cause mortality by nearly 41% (hazard ratio 0.59, 95% CI 0.43 to 0.79) and cardiovascular mortality by 52% (HR 0.48, 95% CI 0.30 to 0.76). Such an effect persisted in most subgroup analyses and complete-case analyses.Conclusion and RelevanceIn this study, we found a protective effect of NPPS against all-cause and cardiovascular mortality in Americans aged 65 years or older. Nonfood pro-, pre-, and synbiotics can be a novel, inexpensive, low-risk treatment addition for all-cause and cardiovascular mortality for older individuals.
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