Journal
RSC ADVANCES
Volume 13, Issue 22, Pages 15001-15005Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d3ra02639f
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Under Lewis acid catalysis, the one-pot domino reaction between ethyl (Z)-3-amino-3-phenylacrylates and 2-amino-N-alkyl/arylbenzamides was used to construct novel spiro [pyrrole-3,2'-quinazoline] carboxylate derivatives. This method combines substituted alkyl/aryl amides with spiro annulated 1H-pyrrole-2,3-diones to produce spiro pyrrole derivatives in good to excellent yields. The current procedure offers advantages such as shorter reaction times, a broad tolerance range for functional groups, and the synthesis of biologically important 2,3-dihydroquinazolin-4(1H)-ones that can participate in organic transformations.
The one-pot domino reaction of ethyl (Z)-3-amino-3-phenylacrylates with 2-amino-N-alkyl/arylbenzamides under Lewis acid catalysis was described as an effective way to construct novel spiro [pyrrole-3,2 '-quinazoline] carboxylate derivatives. By combining substituted alkyl/aryl amides with spiro annulated 1H-pyrrole-2,3-diones, this method provides a novel way for producing spiro pyrrole derivatives in good to excellent yields. The current procedure has a number of benefits, including quicker reaction times, a broad tolerance range for functional groups, and the ability to synthesize 2,3-dihydroquinazolin-4(1H)-ones that are of biological importance and take part in organic transformations. This is the first use of molecular hybridization involving linking with pyrrole derivatives and dihydroquinazolin-4(1H)-ones.
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