4.5 Article

Activation of the JAK/STAT Pathway Leads to BRAF Inhibitor Resistance in BRAFV600E Positive Thyroid Carcinoma

Related references

Note: Only part of the references are listed.
Article Oncology

Genomic and Transcriptomic Correlates of Thyroid Carcinoma Evolution after BRAF Inhibitor Therapy

Mark Lee et al.

Summary: Targeted inhibition of BRAF V600E can control a subset of advanced thyroid tumors, but nearly all the tumors develop resistance and some undergo dedifferentiation. Through analysis of next-generation sequencing data, this study identified molecular alterations associated with thyroid cancer dedifferentiation in the setting of BRAF inhibition. These findings provide insights into the mechanisms of resistance and tumor dedifferentiation.

MOLECULAR CANCER RESEARCH (2022)

Review Oncology

MEK inhibitor resistance mechanisms and recent developments in combination trials

E. Kun et al.

Summary: The MAPK pathway is crucial in cancer development, and drugs targeting this pathway, especially MEK inhibitors, have shown promise. However, research and solutions regarding adaptive resistance mechanisms to MEK inhibitors are still challenging.

CANCER TREATMENT REVIEWS (2021)

Article Oncology

KRAS G12V Mutation in Acquired resistance to Combined BRAF and MEK Inhibition in Papilary Thyroid Cancer

Dwight H. Owen et al.

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK (2019)

Article Oncology

Genetic Analysis of 779 Advanced Differentiated and Anaplastic Thyroid Cancers

Nikita Pozdeyev et al.

CLINICAL CANCER RESEARCH (2018)

Article Endocrinology & Metabolism

Salvage Lenvatinib Therapy in Metastatic Anaplastic Thyroid Cancer

Nicole M. Iniguez-Ariza et al.

THYROID (2017)

Article Oncology

CAR T Therapy Targeting ICAM-1 Eliminates Advanced Human Thyroid Tumors

Irene M. Min et al.

CLINICAL CANCER RESEARCH (2017)

Article Endocrinology & Metabolism

Genomic Landscape of poorly Differentiated and Anaplastic Thyroid Carcinoma

Bin Xu et al.

ENDOCRINE PATHOLOGY (2016)

Article Medicine, Research & Experimental

Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers

Inigo Lancia et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Review Oncology

Antitumour actions of interferons: implications for cancer therapy

Belinda S. Parker et al.

NATURE REVIEWS CANCER (2016)

Article Endocrinology & Metabolism

BRAF Inhibitor Dabrafenib in Patients with Metastatic BRAF-Mutant Thyroid Cancer

Gerald S. Falchook et al.

THYROID (2015)

Article Medicine, General & Internal

Follicular cell-derived thyroid cancer

Henning Dralle et al.

NATURE REVIEWS DISEASE PRIMERS (2015)

Article Biochemistry & Molecular Biology

Integrated Genomic Characterization of Papillary Thyroid Carcinoma

Nishant Agrawal et al.

Article Multidisciplinary Sciences

p53 constrains progression to anaplastic thyroid carcinoma in a Braf-mutant mouse model of papillary thyroid cancer

David G. McFadden et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Biochemical Research Methods

STAR: ultrafast universal RNA-seq aligner

Alexander Dobin et al.

BIOINFORMATICS (2013)

Article Endocrinology & Metabolism

Phase II Trial of Sorafenib in Patients with Advanced Anaplastic Carcinoma of the Thyroid

Panayiotis Savvides et al.

THYROID (2013)

Article Endocrinology & Metabolism

American Thyroid Association Guidelines for Management of Patients with Anaplastic Thyroid Cancer

Robert C. Smallridge et al.

THYROID (2012)

Article Medicine, General & Internal

Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

Paul B. Chapman et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

Article Endocrinology & Metabolism

Clinical implication of hot spot BRAF mutation, V599E, in papillary thyroid cancers

H Namba et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2003)

Article Endocrinology & Metabolism

Antisense hTERT inhibits thyroid cancer cell growth

LS Teng et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2003)