Transcription factor c-Maf-targeted cancer immunotherapy

Article Biochemistry & Molecular Biology

c-Maf enforces cytokine production and promotes memory-like responses in mouse and human type 2 innate lymphoid cells

Sara Trabanelli et al.

Summary: The transcription factor c-Maf is found to be indispensable for optimal type 2 cytokine production and proper memory-like responses in group-2 innate lymphoid cells (ILC2s).

EMBO JOURNAL (2022)

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Article Cell Biology

Nivalenol affects Cyclin B1 level and activates SAC for cell cycle progression in mouse oocyte meiosis

Ping-Shuang Lu et al.

Summary: This study demonstrates that exposure to NIV affects the cell cycle progression in mouse oocyte meiosis by disrupting Cyclin B1 expression and microtubule stability.

CELL PROLIFERATION (2022)

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Article Multidisciplinary Sciences

TCR-Vγδ usage distinguishes protumor from antitumor intestinal γδ T cell subsets

Bernardo S. Reis et al.

Summary: Gamma delta T cells in colorectal cancer (CRC) exhibit distinct phenotypes and functions at different stages of CRC development. In premalignant or non-tumor colons, gamma delta T cells show cytotoxic markers, while tumor-infiltrating gamma delta T cells express a pro-tumorigenic profile.

SCIENCE (2022)

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Article Oncology

Targeting the oncogenic transcription factor c-Maf for the treatment of multiple myeloma

Qiuyun Jiang et al.

Summary: This article provides a concise summary of the advances in c-Maf biology, pathophysiology, and targeted drug discovery for the potential treatment of multiple myeloma (MM).

CANCER LETTERS (2022)

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Article Biochemistry & Molecular Biology

Dysregulation of ILC3s unleashes progression and immunotherapy resistance in colon cancer

Jeremy Goc et al.

Summary: Research shows that ILC3s play a protective role in cancer, and alterations in CRC may lead to dysfunctional adaptive immunity, tumor progression, and immunotherapy resistance.

CELL (2021)

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Article Multidisciplinary Sciences

Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells

Maria Casanova-Acebes et al.

Summary: Macrophages play a crucial role in shaping the tumor microenvironment and tumor immunity, with tissue-resident macrophages identified as key contributors to early lung cancer progression. Targeting tissue-resident macrophages may offer new possibilities for prevention and treatment of early lung cancer lesions.

NATURE (2021)

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Article Biochemistry & Molecular Biology

Constrained TCRγδ-associated Syk activity engages PI3K to facilitate thymic development of IL-17A-secreting γδ T cells

Nital Sumaria et al.

Summary: The study demonstrates that constrained Syk activity optimally engages the PI3K-Akt signaling pathway to promote the development of gamma delta(17) cells and maintain the expression of the IL-17 program. Inhibition of PI3K not only hinders the development of gamma delta(17) cells, but also increases the development of a new subset of gamma delta T cells with a type-I IFN gene expression signature.

SCIENCE SIGNALING (2021)

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Article Immunology