Journal
NEW JOURNAL OF CHEMISTRY
Volume 47, Issue 23, Pages 11123-11133Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d3nj01276j
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The research aims to investigate the regioselectivity and mechanism of the ring-closing reaction of hydrazine derivatives of pyrido[1,2-e]purine. The structure contains two potential nitrogen atoms as nucleophiles. Experimental results show that one nitrogen atom is a more potent nucleophile. Theoretical studies suggest that the regioselectivity is primarily controlled by the kinetic parameters of the reaction, and steric hindrance plays a significant role. Additionally, the aromaticity of the possible final products was analyzed, and it was found that more aromatic products were favored kinetically.
Investigation of the regioselectivity and mechanistic aspects of hydrazine derivatives of pyrido[1,2-e]purine in a ring-closing reaction is the main purpose of this study. The structure possesses two potential nitrogen atoms as nucleophiles in the reaction. Regarding the reported experimental study, one of the nitrogen atoms is a more potent nucleophile. Theoretical studies revealed that the origin of the regioselectivity is rooted in the kinetic parameters of the reaction and the reaction is mainly kinetically controlled. In fact, the steric hindrance of the studied substituents is an effective parameter on the regioselectivity of the ring-closing reaction. Furthermore, the global and local aromatic characteristics of the probable final products were studied. Accordingly, different aromaticity indexes were applied to justify the global and local aromaticity in the obtained products of both the considered routes. Finally, it was concluded that the observed experimental regioselectivity was compatible with the outcomes of the kinetic results. Also, it was revealed that more aromatic products were favorable products, kinetically.
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