Aluminum Phthalocyanine- [60]Fullerene Supramolecular Dyads: Synthesis, Photophysical Properties and ROS Photogeneration

An axially substituted aluminum phthalocyanine-[60]fullerene derivative supramolecular dyads have been prepared. For the first time, such structures were evaluated as the type I photosensitizers for photodynamic therapy (PDT). Compared to the native dye, the fluorescence in the obtained compounds is partially quenched and efficiency of sin-glet oxygen production is reduced. The dyad aluminum phthalocyanine-phenyl-C60-butyric acid encapsulated in poly-vinylpyrrolidone nanop articles showed a threefold increase in the superoxide anion-radical generation compared to the native dye, which indicates the promising potential of this dyad as a type I photosensitizer for PDT.

Automated summary

Axially substituted aluminum phthalocyanine-[60]fullerene derivative supramolecular dyads were synthesized and evaluated as type I photosensitizers for photodynamic therapy (PDT) for the first time. The obtained compounds showed partially quenched fluorescence and reduced singlet oxygen production compared to the native dye. However, the dyad aluminum phthalocyanine-phenyl-C60-butyric acid encapsulated in poly-vinylpyrrolidone nanoparticles exhibited a threefold increase in superoxide anion-radical generation, indicating its promising potential as a type I photosensitizer for PDT.