Visible light-mediated three-component functionalization of olefins with sulfoxyimidoylsulfonium salt for the synthesis of β-amino alcohols and amino ethers

A new strategy involving three-component functionalization of olefins with sulfoxyimidoylsulfonium salt and a nucleophilic reagent for the synthesis of beta-amino alcohols and beta-amino ethers by photoredox catalysis was developed. The sulfoxyimidoylsulfonium salt is important and serves as the N-centred radical precursor. beta-Amino alcohols and beta-amino ethers bearing various functional groups are synthesized in good yields under mild conditions. Furthermore, the advantages of this strategy are greater safety, no additives, and easy to obtain raw materials.

Automated summary

A new strategy for the synthesis of beta-amino alcohols and beta-amino ethers was developed, involving the three-component functionalization of olefins with sulfoxyimidoylsulfonium salt and a nucleophilic reagent using photoredox catalysis. The sulfoxyimidoylsulfonium salt plays a crucial role as the N-centred radical precursor. The strategy allows for the synthesis of beta-amino alcohols and beta-amino ethers with various functional groups in good yields under mild conditions, and offers the advantages of improved safety, no additives, and easy accessibility of raw materials.