Journal
CELL REPORTS
Volume 16, Issue 9, Pages 2289-2297Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2016.07.066
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Funding
- Japanese Ministry of Education, Science, Sports, Culture, and Technology (MEXT)
- Japan Society for the Promotion of Science
- Japan Science and Technology Agency
- Naito foundation
- Basic Research Program of the Japan Science and Technology Agency
- AMED-CREST
- AMED
- NIH [K99-DC013059]
- Grants-in-Aid for Scientific Research [15H04375, 25430081, 16K07077] Funding Source: KAKEN
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Synapse formation requires the precise coordination of axon elongation, cytoskeletal stability, and diverse modes of cell signaling. The underlying mechanisms of this interplay, however, remain unclear. Here, we demonstrate that Strip, a component of the striatin-interacting phosphatase and kinase (STRIPAK) complex that regulates these processes, is required to ensure the proper development of synaptic boutons at the Drosophila neuromuscular junction. In doing so, Strip negatively regulates the activity of the Hippo (Hpo) pathway, an evolutionarily conserved regulator of organ size whose role in synapse formation is currently unappreciated. Strip functions genetically with Enabled, an actin assembly/elongation factor and the presumptive downstream target of Hpo signaling, to modulate local actin organization at synaptic termini. This regulation occurs independently of the transcriptional co-activator Yorkie, the canonical downstream target of the Hpo pathway. Our study identifies a previously unanticipated role of the Strip-Hippo pathway in synaptic development, linking cell signaling to actin organization.
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